Bivariate and multivariable models to demonstrate the association between high fibrocytes and abnormal FEV1 and FVC
| Variable . | Odds ratio (95% CI) . | χ2 . | P . |
|---|---|---|---|
| FEV1 | |||
| Univariate | |||
| Fibrocytes | 4.408 (1.441-13.484) | 6.763 | .009 |
| Age | 0.960 (0.908-1.016) | 2.015 | .156 |
| Transfusion in last 120 d | 4.278 (1.209-15.134) | 5.083 | .024 |
| Hemoglobin | 0.715 (0.496-1.030) | 3.242 | .072 |
| WBC | 1.142 (0.980-1.332) | 2.880 | .090 |
| No. of hospitalizations | 1.042 (0.949-1.144) | 0.750 | .386 |
| Smoking history | 0.970 (0.332-2.833) | 0.032 | .955 |
| Fetal hemoglobin | 0.990 (0.924-1.060) | 0.082 | .775 |
| Sex | 1.412 (0.478-4.168) | 0.390 | .532 |
| Asthma | 1.747 (0.597-5.114) | 1.037 | .309 |
| Multivariable | |||
| Fibrocytes | 4.462 (1.385-14.376) | 6.276 | .012 |
| Transfusion in last 120 d | 4.352 (1.125-16.837) | 4.537 | .033 |
| FVC | |||
| Univariate | |||
| Fibrocytes | 5.573 (1.655-18.771) | 7.688 | .006 |
| Age | 0.942 (0.882-1.006) | 3.212 | .073 |
| Hemoglobin | 0.713 (0.484-1.051) | 2.927 | .087 |
| WBC | 1.128 (0.967-1.317) | 2.344 | .126 |
| No. of hospitalizations | 0.977 (0.873-1.093) | 0.169 | .684 |
| Fetal hemoglobin | 1.016 (0.947-1.091) | 0.204 | .652 |
| Smoking | 0.530 (0.161-1.742) | 1.093 | .296 |
| Transfusion in last 120 d | 2.557 (0.699-9.357) | 2.011 | .156 |
| Asthma | 1.392 (0.447-4.335) | 0.325 | .568 |
| Multivariable | |||
| Fibrocytes | 5.573 (1.655-18.771) | 7.688 | .006 |
| Variable . | Odds ratio (95% CI) . | χ2 . | P . |
|---|---|---|---|
| FEV1 | |||
| Univariate | |||
| Fibrocytes | 4.408 (1.441-13.484) | 6.763 | .009 |
| Age | 0.960 (0.908-1.016) | 2.015 | .156 |
| Transfusion in last 120 d | 4.278 (1.209-15.134) | 5.083 | .024 |
| Hemoglobin | 0.715 (0.496-1.030) | 3.242 | .072 |
| WBC | 1.142 (0.980-1.332) | 2.880 | .090 |
| No. of hospitalizations | 1.042 (0.949-1.144) | 0.750 | .386 |
| Smoking history | 0.970 (0.332-2.833) | 0.032 | .955 |
| Fetal hemoglobin | 0.990 (0.924-1.060) | 0.082 | .775 |
| Sex | 1.412 (0.478-4.168) | 0.390 | .532 |
| Asthma | 1.747 (0.597-5.114) | 1.037 | .309 |
| Multivariable | |||
| Fibrocytes | 4.462 (1.385-14.376) | 6.276 | .012 |
| Transfusion in last 120 d | 4.352 (1.125-16.837) | 4.537 | .033 |
| FVC | |||
| Univariate | |||
| Fibrocytes | 5.573 (1.655-18.771) | 7.688 | .006 |
| Age | 0.942 (0.882-1.006) | 3.212 | .073 |
| Hemoglobin | 0.713 (0.484-1.051) | 2.927 | .087 |
| WBC | 1.128 (0.967-1.317) | 2.344 | .126 |
| No. of hospitalizations | 0.977 (0.873-1.093) | 0.169 | .684 |
| Fetal hemoglobin | 1.016 (0.947-1.091) | 0.204 | .652 |
| Smoking | 0.530 (0.161-1.742) | 1.093 | .296 |
| Transfusion in last 120 d | 2.557 (0.699-9.357) | 2.011 | .156 |
| Asthma | 1.392 (0.447-4.335) | 0.325 | .568 |
| Multivariable | |||
| Fibrocytes | 5.573 (1.655-18.771) | 7.688 | .006 |
High fibrocytes are defined as >1 500 000 cells/mL; abnormal FEV1 and FVC, <5% LLN. The variables in the univariate section for each outcome were chosen by using the information from the tree and requiring an importance of at least 20% in the tree (see supplemental Figure 1A-B).
Bold indicates significance (P < .05).
Abbreviations are explained in Tables 1 and 2.