Characteristics of adults with SCD with low and high circulating fibrocytes
| Median (IQR), n (%), yes . | Low fibrocytes (n = 44) . | High fibrocytes (n = 27) . | P . |
|---|---|---|---|
| Demographics | |||
| Age, median (range) | 33.8 (21.2-59.8) | 31.0 (19.7-63.2) | .20 |
| Female, n (%) | 26 (59.1) | 19 (70.4) | .33 |
| Smoking history, n (%) | 20 (46.5) | 10 (37.0) | .44 |
| HRCT | |||
| No. ≥2 on fibrosis score (%) | 8 (18.2) | 3 (11.5) | .52 |
| Echocardiography | |||
| TR maximum velocity, cm/s | 227.0 (211.9-271.5) | 231.8 (222.2-249.7) | .82 |
| Laboratory values | |||
| Hemoglobin, g/dL | 9.8 (8.7-10.7) | 9.2 (8.1-10.1) | .15 |
| WBC, ×109/L | 8.6 (6.4-10.1) | 9.9 (6.6-11.9) | .08 |
| Reticulocytes, % | 6.3 (3.3-8.3) | 8.6 (4.6-15.0) | .08 |
| Resting SpO2, % | 98.0 (96.5-99.0) | 97.0 (95.0-99.0) | .25 |
| 6-min walk test, m | 376.0 (317.0-418.0) | 374.0 (350.0-417.0) | .57 |
| PFT interpretation pattern, % | .026 | ||
| Normal | 36 (83.7) | 14 (53.9) | |
| Obstructive | 2 (4.7) | 2 (7.7) | |
| Restrictive | 5 (12.1) | 7 (31.8) | |
| Mixed | 0 | 2 (7.7) | |
| Nonspecific | 0 | 1 (3.9) | |
| SCD characteristics | |||
| HbSS, % | 26 (59.1) | 19 (70.4) | .34 |
| Pain length, cm | 2.3 (0.5-4.6) | 2.7 (0.8-4.8) | .79 |
| ACS | 8 (18.2) | 3 (11.1) | .52 |
| Hydroxyurea | 31 (70.5) | 20 (74.1) | .74 |
| Fetal hemoglobin, % | 6.8 (2.1-15.0) | 11.5 (3.2-16.1) | .55 |
| Transfusion in last 120 d, % | 7 (15.9) | 7 (25.9) | .30 |
| Asthma characteristics | |||
| Asthma | 17 (38.6) | 11 (40.7) | .86 |
| Eosinophils, % | 1.0 (1.0-3.0) | 2.0 (2.0-3.0) | .10 |
| Median (IQR), n (%), yes . | Low fibrocytes (n = 44) . | High fibrocytes (n = 27) . | P . |
|---|---|---|---|
| Demographics | |||
| Age, median (range) | 33.8 (21.2-59.8) | 31.0 (19.7-63.2) | .20 |
| Female, n (%) | 26 (59.1) | 19 (70.4) | .33 |
| Smoking history, n (%) | 20 (46.5) | 10 (37.0) | .44 |
| HRCT | |||
| No. ≥2 on fibrosis score (%) | 8 (18.2) | 3 (11.5) | .52 |
| Echocardiography | |||
| TR maximum velocity, cm/s | 227.0 (211.9-271.5) | 231.8 (222.2-249.7) | .82 |
| Laboratory values | |||
| Hemoglobin, g/dL | 9.8 (8.7-10.7) | 9.2 (8.1-10.1) | .15 |
| WBC, ×109/L | 8.6 (6.4-10.1) | 9.9 (6.6-11.9) | .08 |
| Reticulocytes, % | 6.3 (3.3-8.3) | 8.6 (4.6-15.0) | .08 |
| Resting SpO2, % | 98.0 (96.5-99.0) | 97.0 (95.0-99.0) | .25 |
| 6-min walk test, m | 376.0 (317.0-418.0) | 374.0 (350.0-417.0) | .57 |
| PFT interpretation pattern, % | .026 | ||
| Normal | 36 (83.7) | 14 (53.9) | |
| Obstructive | 2 (4.7) | 2 (7.7) | |
| Restrictive | 5 (12.1) | 7 (31.8) | |
| Mixed | 0 | 2 (7.7) | |
| Nonspecific | 0 | 1 (3.9) | |
| SCD characteristics | |||
| HbSS, % | 26 (59.1) | 19 (70.4) | .34 |
| Pain length, cm | 2.3 (0.5-4.6) | 2.7 (0.8-4.8) | .79 |
| ACS | 8 (18.2) | 3 (11.1) | .52 |
| Hydroxyurea | 31 (70.5) | 20 (74.1) | .74 |
| Fetal hemoglobin, % | 6.8 (2.1-15.0) | 11.5 (3.2-16.1) | .55 |
| Transfusion in last 120 d, % | 7 (15.9) | 7 (25.9) | .30 |
| Asthma characteristics | |||
| Asthma | 17 (38.6) | 11 (40.7) | .86 |
| Eosinophils, % | 1.0 (1.0-3.0) | 2.0 (2.0-3.0) | .10 |
Bold indicates significance (P < .05).
Abbreviations are explained in Tables 1 and 2.