Genetic analysis of stem and progenitor cells in lymphoid disease
| Material . | CLL . | DLBCL . | FL . | MCL . | HCL . | TCL . |
|---|---|---|---|---|---|---|
| CD34+ HSC | +mut19,22 | −mut23 | — | — | +mut53 | +mut41,103 |
| CLP | +mut19 | — | +mut25,26 (in silico) | CD45+ with t(11;14)101 | +mut53 | — |
| Normal tissue (blood sample, buccal swabs) | — | +mut41 | — | — | +mut114 | +mut41,54 |
| Proposed COO86 | Naïve B cell | Activated/germinal center B cell | Centrocyte | Mantle cell | Mature B cell | Different T-cell subtypes |
| Material . | CLL . | DLBCL . | FL . | MCL . | HCL . | TCL . |
|---|---|---|---|---|---|---|
| CD34+ HSC | +mut19,22 | −mut23 | — | — | +mut53 | +mut41,103 |
| CLP | +mut19 | — | +mut25,26 (in silico) | CD45+ with t(11;14)101 | +mut53 | — |
| Normal tissue (blood sample, buccal swabs) | — | +mut41 | — | — | +mut114 | +mut41,54 |
| Proposed COO86 | Naïve B cell | Activated/germinal center B cell | Centrocyte | Mantle cell | Mature B cell | Different T-cell subtypes |
—, material has not been genetically analyzed with genetic sequencing; CLP, common lymphoid progenitor; COO, cell of origin; mut, mutation; +mut, material in the specified disease has been found to have a genetic defect also found in the lymphoid tumors; −mut, material in the specified disease has not been found to have a genetic defect comparable to that of lymphoid tumors.