Relationship among age, year of HSCT, JACIE accreditation status, mean center size, and outcome of autologous HSCT for AD using multivariate Cox analysis
| . | Relapse HR (95% CI) . | NRM HR (95% CI) . | NRM day 100 HR (95% CI) . | PFS HR (95% CI) . | OS HR (95% CI) . |
|---|---|---|---|---|---|
| Age (at transplant) per 10-y period | 1.00 (0.90-1.11) | 1.51 (1.14-2.02) | 1.73 (1.17-2.55) | 1.05 (0.95-1.16) | 1.35 (1.15-1.58) |
| P | .97 | .005 | .006 | .32 | .0002 |
| MS (reference) | 1 | 1 | 1 | 1 | 1 |
| SSc | 0.9 (0.70-1.16) | 3.10 (1.50-6.41) | 3.05 (1.21-7.70) | 1.04 (0.83-1.31) | 3.18 (2.18-4.66) |
| P | .41 | .002 | .018 | .72 | <10−5 |
| CD | 2.42 (1.73-3.39) | 0.82 (0.11-6.36) | 1.08 (0.13-8.80) | 2.32 (1.67-3.22) | 0.68 (0.21-2.21) |
| P | <10−5 | .85 | .94 | <10−5 | .53 |
| ≥23 autologous HSCT for AD (experience) | 0.77 (0.62-0.95) | 0.36 (0.18-0.73) | 0.29 (0.11-0.74) | 0.72 (0.59-0.88) | 0.62 (0.44-0.88) |
| P | .017 | .004 | .010 | .001 | .007 |
| ≥6 y from first HSCT for AD (learning) | 0.78 (0.60-0.97) | 0.55 (0.26-1.16) | 0.35 (0.14-0.89) | 0.74 (0.59-0.93) | 0.89 (0.59-1.34) |
| P | .02 | .12 | .028 | .010 | .58 |
| After JACIE | 0.70 (0.50-0.98) | 0.37 (0.11-1.27) | 0.55 (0.15-1.94) | 0.67 (0.49-0.93) | 0.59 (0.33-1.08) |
| P | .04 | .12 | .35 | .015 | .087 |
| ≥42 autos/y for any indication (mean center size) | 1.03 (0.84-1.27) | 0.95 (0.50-1.80) | 1.26 (0.56-2.85) | 1.03 (0.85-1.26) | 0.90 (0.64-1.27) |
| P | .76 | .88 | .58 | .76 | .54 |
| . | Relapse HR (95% CI) . | NRM HR (95% CI) . | NRM day 100 HR (95% CI) . | PFS HR (95% CI) . | OS HR (95% CI) . |
|---|---|---|---|---|---|
| Age (at transplant) per 10-y period | 1.00 (0.90-1.11) | 1.51 (1.14-2.02) | 1.73 (1.17-2.55) | 1.05 (0.95-1.16) | 1.35 (1.15-1.58) |
| P | .97 | .005 | .006 | .32 | .0002 |
| MS (reference) | 1 | 1 | 1 | 1 | 1 |
| SSc | 0.9 (0.70-1.16) | 3.10 (1.50-6.41) | 3.05 (1.21-7.70) | 1.04 (0.83-1.31) | 3.18 (2.18-4.66) |
| P | .41 | .002 | .018 | .72 | <10−5 |
| CD | 2.42 (1.73-3.39) | 0.82 (0.11-6.36) | 1.08 (0.13-8.80) | 2.32 (1.67-3.22) | 0.68 (0.21-2.21) |
| P | <10−5 | .85 | .94 | <10−5 | .53 |
| ≥23 autologous HSCT for AD (experience) | 0.77 (0.62-0.95) | 0.36 (0.18-0.73) | 0.29 (0.11-0.74) | 0.72 (0.59-0.88) | 0.62 (0.44-0.88) |
| P | .017 | .004 | .010 | .001 | .007 |
| ≥6 y from first HSCT for AD (learning) | 0.78 (0.60-0.97) | 0.55 (0.26-1.16) | 0.35 (0.14-0.89) | 0.74 (0.59-0.93) | 0.89 (0.59-1.34) |
| P | .02 | .12 | .028 | .010 | .58 |
| After JACIE | 0.70 (0.50-0.98) | 0.37 (0.11-1.27) | 0.55 (0.15-1.94) | 0.67 (0.49-0.93) | 0.59 (0.33-1.08) |
| P | .04 | .12 | .35 | .015 | .087 |
| ≥42 autos/y for any indication (mean center size) | 1.03 (0.84-1.27) | 0.95 (0.50-1.80) | 1.26 (0.56-2.85) | 1.03 (0.85-1.26) | 0.90 (0.64-1.27) |
| P | .76 | .88 | .58 | .76 | .54 |
Hazard ratio (HR) <1 = good prognosis.
Autos, autologous HSCTs.