Improvement with 3-y outcomes over time epochs in patients undergoing first autologous HSCT with intermediate intensity conditioning regimens
| . | N . | RI/progression, % (95% CI) . | NRM, % (95% CI) . | 100-d NRM, % (95% CI) . | PFS, % (95% CI) . | OS, % (95% CI) . |
|---|---|---|---|---|---|---|
| 1995-1999 | 140 | 42.8 (34.4-50.9) | 7.2 (3.7-12.3) | 7.2 (3.7-12.3) | 50 (41.7-58.4) | 85.6 (79.8-91.5) |
| 2000-2004 | 199 | 37.3 (30.4-44.2) | 5.8 (3.1-9.7) | 4.7 (2.3-8.4) | 56.9 (49.8-64) | 88.1 (83.6-92.7) |
| 2005-2010 | 470 | 29.1 (24.6-33.8) | 4.9 (3.1-7.3) | 3.9 (2.4-6.1) | 65.9 (61.1-70.7) | 89.1 (86.1-92.1) |
| 2011-2015 | 650 | 33.8 (27.3-40.4) | 1.4 (0.6-2.8) | 1.2 (0.5-2.4) | 64.8 (58.2-71.4) | 93.6 (90.7-96.6) |
| P | .001 | .002 | .002 | <105 | .006 |
| . | N . | RI/progression, % (95% CI) . | NRM, % (95% CI) . | 100-d NRM, % (95% CI) . | PFS, % (95% CI) . | OS, % (95% CI) . |
|---|---|---|---|---|---|---|
| 1995-1999 | 140 | 42.8 (34.4-50.9) | 7.2 (3.7-12.3) | 7.2 (3.7-12.3) | 50 (41.7-58.4) | 85.6 (79.8-91.5) |
| 2000-2004 | 199 | 37.3 (30.4-44.2) | 5.8 (3.1-9.7) | 4.7 (2.3-8.4) | 56.9 (49.8-64) | 88.1 (83.6-92.7) |
| 2005-2010 | 470 | 29.1 (24.6-33.8) | 4.9 (3.1-7.3) | 3.9 (2.4-6.1) | 65.9 (61.1-70.7) | 89.1 (86.1-92.1) |
| 2011-2015 | 650 | 33.8 (27.3-40.4) | 1.4 (0.6-2.8) | 1.2 (0.5-2.4) | 64.8 (58.2-71.4) | 93.6 (90.7-96.6) |
| P | .001 | .002 | .002 | <105 | .006 |