Table 1. Summarized chimerism data of CA... | American Society of Hematology

Table 1.

Summarized chimerism data of CA mice and control mice in the absence of cytoreductive conditioning and with reduced-intensity myeloablation

Genotype	n	Conditioning		Final RBC chimerism	HSPC chimerism	Granulocyte chimerism
α₂α₁/α₂α₁, γ^HPFHβ⁰/γ^HPFHβ⁰	12	anti-CD122, Diprotin A	Mean	87.9*	5.2	4.8
			Range	59.3-98.9	0.5-15.7	0.8-10.6
			SEM	3.67	1.28	1.07
α₂α₁/α₂α₁, γ^HPFHβ⁰/+	7		Mean	1.2*	ND	1.7
			Range	0.0-4.2		0.0-6.0
			SEM	0.63		0.87
α₂α₁/α₂α₁, +/+	5		Mean	2.6*	ND	1.5
			Range	0.0-6.1		0.0-6.4
			SEM	1.35		1.24
α₂α₁/α₂α₁, γ^HPFHβ⁰/γ^HPFHβ⁰	5	400 rad	Mean	99.7	57.7	59.5
			Range	98.8-99.9	15.1-97.1	18.8-83.7
			SEM	0.22	16.84	12.91

Genotype	n	Conditioning		Final RBC chimerism	HSPC chimerism	Granulocyte chimerism
α₂α₁/α₂α₁, γ^HPFHβ⁰/γ^HPFHβ⁰	12	anti-CD122, Diprotin A	Mean	87.9*	5.2	4.8
			Range	59.3-98.9	0.5-15.7	0.8-10.6
			SEM	3.67	1.28	1.07
α₂α₁/α₂α₁, γ^HPFHβ⁰/+	7		Mean	1.2*	ND	1.7
			Range	0.0-4.2		0.0-6.0
			SEM	0.63		0.87
α₂α₁/α₂α₁, +/+	5		Mean	2.6*	ND	1.5
			Range	0.0-6.1		0.0-6.4
			SEM	1.35		1.24
α₂α₁/α₂α₁, γ^HPFHβ⁰/γ^HPFHβ⁰	5	400 rad	Mean	99.7	57.7	59.5
			Range	98.8-99.9	15.1-97.1	18.8-83.7
			SEM	0.22	16.84	12.91

Chimerism data were collected after 150 d upon euthanasia of recipients. Chimerism values represent percentage of GFP⁺ donor cells among RBCs, HSPCs (Lin^–Sca1⁺cKit⁺), and granulocytes (Gr1⁺). Means, ranges, and SEMs are shown. RBC chimerism was significantly different between CA mice and control mice as determined by 1-way analysis of variance. By the same test, there was no statistically significant difference between granulocyte chimerism levels within the groups undergoing noncytoreductive conditioning.

ND, not determined.

P ≤ .00001.

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