Incidence of AL amyloidosis in years 2012 to 2015
| . | . | No. of cases per million person-years (numerator/denominator*) . | APC† . | ||||
|---|---|---|---|---|---|---|---|
| Sex . | Age, y . | 2012 . | 2013 . | 2014 . | 2015 . | APC %† (95% CI) . | P‡ . |
| Female | 18-34 | 0.7 (3/4 166 829) | 0.9 (3/3 310 183) | 1.2 (4/3 359 080) | 1.3 (3/2 304 754) | 10.8 (−6.4 to 31.2) | .178 |
| 35-54 | 5.5 (37/6 715 540) | 7.3 (38/5 216 573) | 6.9 (36/5 179 870) | 6.9 (24/3 472 683) | 3.2 (−2.5 to 9.2) | .226 | |
| 55-64 | 15.0 (50/3 328 882) | 17.6 (47/2 667 972) | 17.0 (45/2 651 934) | 19.7 (37/1 882 131) | 2.7 (−5.4 to 11.4) | .457 | |
| 65+ | 33.4 (63/1 886 895) | 39.2 (65/1 658 812) | 40.8 (58/1 421 356) | 31.9 (30/941 145) | 5.2 (−2.4 to 13.3) | .152 | |
| All female | 9.5 (153/16 098 146) | 11.9 (153/12 853 540) | 11.3 (143/12 612 240) | 10.9 (94/8 600 713) | 3.7 (0.1-7.5) | .045 | |
| Male | 18-34 | 1.0 (4/3 967 934) | 0.3 (1/3 118 956) | 0.0 (0/3 192 462) | 0.0 (0/2 189 512) | −4.5 (−43.0 to 59.9) | .794 |
| 35-54 | 6.0 (36/6 031 186) | 7.4 (34/4 591 304) | 5.7 (26/4 590 403) | 4.9 (15/3 036 880) | 3.9 (−6.6 to 15.5) | .413 | |
| 55-64 | 24.1 (71/2 949 686) | 23.4 (54/2 305 454) | 23.0 (53/2 309 138) | 21.1 (34/1 610 218) | 2.7 (−4.9 to 10.8) | .427 | |
| 65+ | 74.9 (113/1 508 927) | 71.6 (97/1 355 492) | 63.2 (75/1 186 149) | 60.3 (46/762 658) | 2.3 (−1.9 to 6.7) | .237 | |
| All male | 15.5 (224/14 457 733) | 16.4 (186/11 371 206) | 13.7 (154/11 278 152) | 12.5 (95/7 599 268) | 2.5 (−3.1 to 8.5) | .326 | |
| All sex | 18-34 | 0.9 (7/8 134 763) | 0.6 (4/6 429 139) | 0.6 (4/6 551 542) | 0.7 (3/4 494 266) | 7.4 (−13.8 to 33.9) | .456 |
| 35-54 | 5.7 (73/12 746 726) | 7.3 (72/9 807 877) | 6.3 (62/9 770 273) | 6.0 (39/6 509 563) | 3.5 (−3.5 to 10.9) | .274 | |
| 55-64 | 19.3 (121/6 278 568) | 20.3 (101/4 973 426) | 19.8 (98/4 961 072) | 20.3 (71/3 492 349) | 2.7 (−4.5 to 10.5) | .408 | |
| 65+ | 51.8 (176/3 395 822) | 53.7 (162/3 014 304) | 51.0 (133/2 607 505) | 44.6 (76/1 703 803) | 3.4 (−0.8 to 7.7) | .096 | |
| All patients | 12.3 (377/30 555 879) | 14.0 (339/24 224 746) | 12.4 (297/23 890 392) | 11.7 (189/16 199 981) | 3.1 (−1.0 to 7.3) | .114 | |
| US adult population | Age-sex adjusted§rate, no. of cases per million person-years | ||||||
| Female | 10.9 | 13.1 | 13.3 | 12.0 | 4.1 (0.1-8.3) | .045 | |
| Male | 17.8 | 17.5 | 15.4 | 14.4 | 2.3 (−2.9 to 7.8) | .331 | |
| All | 14.2 | 15.2 | 14.3 | 13.2 | 3.1 (−0.8 to 7.1) | .098 | |
| . | . | No. of cases per million person-years (numerator/denominator*) . | APC† . | ||||
|---|---|---|---|---|---|---|---|
| Sex . | Age, y . | 2012 . | 2013 . | 2014 . | 2015 . | APC %† (95% CI) . | P‡ . |
| Female | 18-34 | 0.7 (3/4 166 829) | 0.9 (3/3 310 183) | 1.2 (4/3 359 080) | 1.3 (3/2 304 754) | 10.8 (−6.4 to 31.2) | .178 |
| 35-54 | 5.5 (37/6 715 540) | 7.3 (38/5 216 573) | 6.9 (36/5 179 870) | 6.9 (24/3 472 683) | 3.2 (−2.5 to 9.2) | .226 | |
| 55-64 | 15.0 (50/3 328 882) | 17.6 (47/2 667 972) | 17.0 (45/2 651 934) | 19.7 (37/1 882 131) | 2.7 (−5.4 to 11.4) | .457 | |
| 65+ | 33.4 (63/1 886 895) | 39.2 (65/1 658 812) | 40.8 (58/1 421 356) | 31.9 (30/941 145) | 5.2 (−2.4 to 13.3) | .152 | |
| All female | 9.5 (153/16 098 146) | 11.9 (153/12 853 540) | 11.3 (143/12 612 240) | 10.9 (94/8 600 713) | 3.7 (0.1-7.5) | .045 | |
| Male | 18-34 | 1.0 (4/3 967 934) | 0.3 (1/3 118 956) | 0.0 (0/3 192 462) | 0.0 (0/2 189 512) | −4.5 (−43.0 to 59.9) | .794 |
| 35-54 | 6.0 (36/6 031 186) | 7.4 (34/4 591 304) | 5.7 (26/4 590 403) | 4.9 (15/3 036 880) | 3.9 (−6.6 to 15.5) | .413 | |
| 55-64 | 24.1 (71/2 949 686) | 23.4 (54/2 305 454) | 23.0 (53/2 309 138) | 21.1 (34/1 610 218) | 2.7 (−4.9 to 10.8) | .427 | |
| 65+ | 74.9 (113/1 508 927) | 71.6 (97/1 355 492) | 63.2 (75/1 186 149) | 60.3 (46/762 658) | 2.3 (−1.9 to 6.7) | .237 | |
| All male | 15.5 (224/14 457 733) | 16.4 (186/11 371 206) | 13.7 (154/11 278 152) | 12.5 (95/7 599 268) | 2.5 (−3.1 to 8.5) | .326 | |
| All sex | 18-34 | 0.9 (7/8 134 763) | 0.6 (4/6 429 139) | 0.6 (4/6 551 542) | 0.7 (3/4 494 266) | 7.4 (−13.8 to 33.9) | .456 |
| 35-54 | 5.7 (73/12 746 726) | 7.3 (72/9 807 877) | 6.3 (62/9 770 273) | 6.0 (39/6 509 563) | 3.5 (−3.5 to 10.9) | .274 | |
| 55-64 | 19.3 (121/6 278 568) | 20.3 (101/4 973 426) | 19.8 (98/4 961 072) | 20.3 (71/3 492 349) | 2.7 (−4.5 to 10.5) | .408 | |
| 65+ | 51.8 (176/3 395 822) | 53.7 (162/3 014 304) | 51.0 (133/2 607 505) | 44.6 (76/1 703 803) | 3.4 (−0.8 to 7.7) | .096 | |
| All patients | 12.3 (377/30 555 879) | 14.0 (339/24 224 746) | 12.4 (297/23 890 392) | 11.7 (189/16 199 981) | 3.1 (−1.0 to 7.3) | .114 | |
| US adult population | Age-sex adjusted§rate, no. of cases per million person-years | ||||||
| Female | 10.9 | 13.1 | 13.3 | 12.0 | 4.1 (0.1-8.3) | .045 | |
| Male | 17.8 | 17.5 | 15.4 | 14.4 | 2.3 (−2.9 to 7.8) | .331 | |
| All | 14.2 | 15.2 | 14.3 | 13.2 | 3.1 (−0.8 to 7.1) | .098 | |
Number of members enrolled with a health plan from July 1st of previous year to June 30th of the calendar year.
APC (for Tables 6 and 7).
P value reflects whether the APC is significantly different from zero (for Tables 6 and 7).
Based on US 2010 census data. Overall rates were adjusted by age and sex distribution, and rates by sex were adjusted by age distribution within specific sex.