Plasma clot formation and fibrinolysis parameters: presence of CTI
| . | All samples . | Partial FXI deficiency . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| . | C, mean ± SD . | NB, mean ± SD . | B, mean ± SD . | P, C vs NB* . | P, C vs B* . | P, NB vs B (adj)*† . | NB . | B . | P, NB vs B (adj)*† . |
| Clotting, N | 49 | 40 | 18 | 38 | 12 | ||||
| Onset time, min | 29.0 ± 24.7 | 25.2 ± 18.0 | 46.9 ± 41.9 | .888 | .118 | .079 (.036) | 25.4 ± 18.3 | 34.0 ± 30.3 | .517 (.195) |
| Vmax, mOD/min | 46.3 ± 20.4 | 37.1 ± 16.8 | 22.2 ± 21.6 | .004 | .000 | .002 (.009) | 36.9 ± 16.6 | 26.8 ± 22.1 | .035 (.062) |
| Time to plateau, min | 54.5 ± 27.2 | 62.4 ± 27.6 | 81.7 ± 34.7 | .142 | .006 | .033 (.060) | 62.5 ± 27.8 | 73.0 ± 33.3 | .237 (.236) |
| Peak turbidity change | 0.57 ± 0.17 | 0.62 ± 0.16 | 0.41 ± 0.26 | .108 | .010 | .001 (.002) | 0.62 ± 0.16 | 0.47 ± 0.21 | .009 (.012) |
| Clotting + TM, N | 49 | 40 | 18 | 38 | 12 | ||||
| Onset time, min | 58.7 ± 36.4 | 71.2 ± 41.2 | 84.6 ± 40.5 | .217 | .025 | .226 (.376) | 72.9 ± 41.8 | 84.4 ± 40.0 | .382 (.526) |
| Vmax, mOD/min | 23.8 ± 20.0 | 15.1 ± 16.6 | 12.8 ± 22.8 | .031 | .011 | .308 (.435) | 14.6 ± 16.4 | 10.2 ± 15.4 | .395 (.424) |
| Time to plateau, min | 89.8 ± 28.8 | 99.7 ± 27.6 | 106.4 ± 27.6 | .068 | .011 | .269 (.378) | 100.2 ± 27.3 | 107.2 ± 23.7 | .603 (.463) |
| Peak turbidity change | 0.38 ± 0.26 | 0.32 ± 0.30 | 0.18 ± 0.27 | .416 | .008 | .134 (.107) | 0.31 ± 0.30 | 0.17 ± 0.26 | .211 (.210) |
| Clotted samples, N (%)‡ | 39 (80) | 25 (63) | 9 (50) | .076 | .016 | .356 (.529) | 23 (61) | 6 (50) | .505 (.654) |
| Fibrinolysis, N | 49 | 39 | 18 | 37 | 12 | ||||
| Onset time, min | 27.7 ± 14.9 | 28.5 ± 21.8 | 55.9 ± 42.3 | .562 | .026 | .026 (.036) | 28.5 ± 22.2 | 44.6 ± 33.4 | .106 (.092) |
| Vmax, mOD/min | 67.7 ± 24.1 | 52.7 ± 23.7 | 27.3 ± 25.2 | .004 | .000 | .000 (.008) | 53.2 ± 23.8 | 33.8 ± 24.9 | .006 (.023) |
| Time to peak, min | 44.3 ± 16.7 | 46.2 ± 19.6 | 71.7 ± 37.6 | .684 | .011 | .022 (.026) | 46.4 ± 2.1 | 62.0 ± 3.7 | .114 (.068) |
| Peak turbidity change | 0.47 ± 0.13 | 0.41 ± 0.15 | 0.25 ± 0.19 | .125 | .000 | .001 (.010) | 0.42 ± 0.15 | 0.29 ± 0.16 | .010 (.026) |
| AUC | 577.7 ± 260.5 | 518.0 ± 304.7 | 260.1 ± 252.5 | .164 | .000 | .011 (.023) | 527.0 ± 310.3 | 295.9 ± 185.3 | .009 (.029) |
| Lysis time, min | 26.0 ± 8.4 | 23.4 ± 10.8 | 15.3 ± 11.6 | .086 | .002 | .029 (.151) | 23.6 ± 11.0 | 19.1 ± 9.1 | .214 (.280) |
| . | All samples . | Partial FXI deficiency . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| . | C, mean ± SD . | NB, mean ± SD . | B, mean ± SD . | P, C vs NB* . | P, C vs B* . | P, NB vs B (adj)*† . | NB . | B . | P, NB vs B (adj)*† . |
| Clotting, N | 49 | 40 | 18 | 38 | 12 | ||||
| Onset time, min | 29.0 ± 24.7 | 25.2 ± 18.0 | 46.9 ± 41.9 | .888 | .118 | .079 (.036) | 25.4 ± 18.3 | 34.0 ± 30.3 | .517 (.195) |
| Vmax, mOD/min | 46.3 ± 20.4 | 37.1 ± 16.8 | 22.2 ± 21.6 | .004 | .000 | .002 (.009) | 36.9 ± 16.6 | 26.8 ± 22.1 | .035 (.062) |
| Time to plateau, min | 54.5 ± 27.2 | 62.4 ± 27.6 | 81.7 ± 34.7 | .142 | .006 | .033 (.060) | 62.5 ± 27.8 | 73.0 ± 33.3 | .237 (.236) |
| Peak turbidity change | 0.57 ± 0.17 | 0.62 ± 0.16 | 0.41 ± 0.26 | .108 | .010 | .001 (.002) | 0.62 ± 0.16 | 0.47 ± 0.21 | .009 (.012) |
| Clotting + TM, N | 49 | 40 | 18 | 38 | 12 | ||||
| Onset time, min | 58.7 ± 36.4 | 71.2 ± 41.2 | 84.6 ± 40.5 | .217 | .025 | .226 (.376) | 72.9 ± 41.8 | 84.4 ± 40.0 | .382 (.526) |
| Vmax, mOD/min | 23.8 ± 20.0 | 15.1 ± 16.6 | 12.8 ± 22.8 | .031 | .011 | .308 (.435) | 14.6 ± 16.4 | 10.2 ± 15.4 | .395 (.424) |
| Time to plateau, min | 89.8 ± 28.8 | 99.7 ± 27.6 | 106.4 ± 27.6 | .068 | .011 | .269 (.378) | 100.2 ± 27.3 | 107.2 ± 23.7 | .603 (.463) |
| Peak turbidity change | 0.38 ± 0.26 | 0.32 ± 0.30 | 0.18 ± 0.27 | .416 | .008 | .134 (.107) | 0.31 ± 0.30 | 0.17 ± 0.26 | .211 (.210) |
| Clotted samples, N (%)‡ | 39 (80) | 25 (63) | 9 (50) | .076 | .016 | .356 (.529) | 23 (61) | 6 (50) | .505 (.654) |
| Fibrinolysis, N | 49 | 39 | 18 | 37 | 12 | ||||
| Onset time, min | 27.7 ± 14.9 | 28.5 ± 21.8 | 55.9 ± 42.3 | .562 | .026 | .026 (.036) | 28.5 ± 22.2 | 44.6 ± 33.4 | .106 (.092) |
| Vmax, mOD/min | 67.7 ± 24.1 | 52.7 ± 23.7 | 27.3 ± 25.2 | .004 | .000 | .000 (.008) | 53.2 ± 23.8 | 33.8 ± 24.9 | .006 (.023) |
| Time to peak, min | 44.3 ± 16.7 | 46.2 ± 19.6 | 71.7 ± 37.6 | .684 | .011 | .022 (.026) | 46.4 ± 2.1 | 62.0 ± 3.7 | .114 (.068) |
| Peak turbidity change | 0.47 ± 0.13 | 0.41 ± 0.15 | 0.25 ± 0.19 | .125 | .000 | .001 (.010) | 0.42 ± 0.15 | 0.29 ± 0.16 | .010 (.026) |
| AUC | 577.7 ± 260.5 | 518.0 ± 304.7 | 260.1 ± 252.5 | .164 | .000 | .011 (.023) | 527.0 ± 310.3 | 295.9 ± 185.3 | .009 (.029) |
| Lysis time, min | 26.0 ± 8.4 | 23.4 ± 10.8 | 15.3 ± 11.6 | .086 | .002 | .029 (.151) | 23.6 ± 11.0 | 19.1 ± 9.1 | .214 (.280) |