Plasma clot formation and fibrinolysis parameters: absence of CTI
| . | All samples . | Partial FXI deficiency . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| . | C, mean ± SD . | NB, mean ± SD . | B, mean ± SD . | P, C vs NB* . | P, C vs B* . | P, NB vs B (adj)*† . | NB . | B . | P, NB vs B (adj)*† . |
| Clotting, N | 49 | 46 | 23 | 40 | 15 | ||||
| Onset time, min | 9.2 ± 6.1 | 20.6 ± 23.0 | 22.0 ± 24.4 | .000 | .001 | .889 (.238) | 15.3 ± 7.4 | 14.1 ± 6.8 | .895 (.456) |
| Vmax, mOD/min | 258.2 ± 60.6 | 190.9 ± 94.3 | 143.2 ± 94.1 | .000 | .000 | .021 (.442) | 214.9 ± 74.8 | 190.8 ± 76.2 | .162 (.286) |
| Time to plateau, min | 16.7 ± 6.2 | 31.1 ± 26.2 | 42.4 ± 36.2 | .000 | .000 | .033 (.922) | 23.3 ± 8.1 | 24.7 ± 6.1 | .303 (.709) |
| Peak turbidity change | 0.71 ± 0.12 | 0.68 ± 0.22 | 0.69 ± 0.21 | .339 | .690 | .736 (.295) | 0.71 ± 0.17 | 0.75 ± 0.16 | .467 (.491) |
| Clotting + TM, N | 49 | 46 | 23 | 40 | 15 | ||||
| Onset time, min | 11.5 ± 5.8 | 27.9 ± 34.9 | 40.1 ± 56.4 | .000 | .000 | .959 (.999) | 20.2 ± 10.7 | 20.4 ± 10.0 | .932 (.941) |
| Vmax, mOD/min | 267.3 ± 72.8 | 200.2 ± 96.4 | 129.0 ± 79.1 | .000 | .000 | .001 (.023) | 224.7 ± 75.3 | 173.0 ± 51.6 | .006 (.007) |
| Time to plateau, min | 18.3 ± 6.2 | 38.5 ± 36.0 | 53.1 ± 51.4 | .000 | .000 | .081 (.908) | 27.8 ± 10.0 | 30.9 ± 11.2 | .400 (.380) |
| Peak turbidity change | 0.71 ± 0.16 | 0.67 ± 0.20 | 0.65 ± 0.30 | .594 | .923 | .664 (.446) | 0.70 ± 0.14 | 0.76 ± 0.16 | .192 (.158) |
| Clotted samples, N (%)‡ | 49 (100) | 44 (96) | 20 (87) | .160 | .011 | .170 (.864) | 40 (100) | 15 (100) | 1.00 (1.00) |
| Fibrinolysis, N | 49 | 46 | 23 | 40 | 15 | ||||
| Onset time, min | 9.5 ± 5.8 | 18.6 ± 25.9 | 35.9 ± 58.0 | .000 | .043 | .775 (.658) | 14.1 ± 8.3 | 13.7 ± 8.6 | .940 (.764) |
| Vmax, mOD/min | 260.2 ± 58.2 | 184.7 ± 86.3 | 131.2 ± 83.5 | .000 | .000 | .015 (.125) | 205.3 ± 71.3 | 177.3 ± 57.8 | .174 (.124) |
| Time to peak, min | 19.5 ± 6.9 | 33.2 ± 26.7 | 52.4 ± 53.4 | .000 | .000 | .198 (.624) | 26.8 ± 10.4 | 28.4 ± 10.2 | .478 (.676) |
| Peak turbidity change | 0.71 ± 0.13 | 0.71 ± 0.18 | 0.64 ± 0.30 | .607 | .461 | .314 (.240) | 0.73 ± 0.15 | 0.76 ± 0.19 | .977 (.622) |
| AUC | 3133 ± 1171 | 3035 ± 1197 | 2892 ± 1792 | .829 | .422 | .472 (.104) | 3165 ± 1144 | 3603 ± 1599 | .610 (.301) |
| Lysis time, min | 113.9 ± 33.5 | 115.4 ± 42.2 | 115.4 ± 52.3 | .663 | .291 | .756 (.884) | 122.3 ± 36.6 | 136.9 ± 23.6 | .307 (.192) |
| . | All samples . | Partial FXI deficiency . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| . | C, mean ± SD . | NB, mean ± SD . | B, mean ± SD . | P, C vs NB* . | P, C vs B* . | P, NB vs B (adj)*† . | NB . | B . | P, NB vs B (adj)*† . |
| Clotting, N | 49 | 46 | 23 | 40 | 15 | ||||
| Onset time, min | 9.2 ± 6.1 | 20.6 ± 23.0 | 22.0 ± 24.4 | .000 | .001 | .889 (.238) | 15.3 ± 7.4 | 14.1 ± 6.8 | .895 (.456) |
| Vmax, mOD/min | 258.2 ± 60.6 | 190.9 ± 94.3 | 143.2 ± 94.1 | .000 | .000 | .021 (.442) | 214.9 ± 74.8 | 190.8 ± 76.2 | .162 (.286) |
| Time to plateau, min | 16.7 ± 6.2 | 31.1 ± 26.2 | 42.4 ± 36.2 | .000 | .000 | .033 (.922) | 23.3 ± 8.1 | 24.7 ± 6.1 | .303 (.709) |
| Peak turbidity change | 0.71 ± 0.12 | 0.68 ± 0.22 | 0.69 ± 0.21 | .339 | .690 | .736 (.295) | 0.71 ± 0.17 | 0.75 ± 0.16 | .467 (.491) |
| Clotting + TM, N | 49 | 46 | 23 | 40 | 15 | ||||
| Onset time, min | 11.5 ± 5.8 | 27.9 ± 34.9 | 40.1 ± 56.4 | .000 | .000 | .959 (.999) | 20.2 ± 10.7 | 20.4 ± 10.0 | .932 (.941) |
| Vmax, mOD/min | 267.3 ± 72.8 | 200.2 ± 96.4 | 129.0 ± 79.1 | .000 | .000 | .001 (.023) | 224.7 ± 75.3 | 173.0 ± 51.6 | .006 (.007) |
| Time to plateau, min | 18.3 ± 6.2 | 38.5 ± 36.0 | 53.1 ± 51.4 | .000 | .000 | .081 (.908) | 27.8 ± 10.0 | 30.9 ± 11.2 | .400 (.380) |
| Peak turbidity change | 0.71 ± 0.16 | 0.67 ± 0.20 | 0.65 ± 0.30 | .594 | .923 | .664 (.446) | 0.70 ± 0.14 | 0.76 ± 0.16 | .192 (.158) |
| Clotted samples, N (%)‡ | 49 (100) | 44 (96) | 20 (87) | .160 | .011 | .170 (.864) | 40 (100) | 15 (100) | 1.00 (1.00) |
| Fibrinolysis, N | 49 | 46 | 23 | 40 | 15 | ||||
| Onset time, min | 9.5 ± 5.8 | 18.6 ± 25.9 | 35.9 ± 58.0 | .000 | .043 | .775 (.658) | 14.1 ± 8.3 | 13.7 ± 8.6 | .940 (.764) |
| Vmax, mOD/min | 260.2 ± 58.2 | 184.7 ± 86.3 | 131.2 ± 83.5 | .000 | .000 | .015 (.125) | 205.3 ± 71.3 | 177.3 ± 57.8 | .174 (.124) |
| Time to peak, min | 19.5 ± 6.9 | 33.2 ± 26.7 | 52.4 ± 53.4 | .000 | .000 | .198 (.624) | 26.8 ± 10.4 | 28.4 ± 10.2 | .478 (.676) |
| Peak turbidity change | 0.71 ± 0.13 | 0.71 ± 0.18 | 0.64 ± 0.30 | .607 | .461 | .314 (.240) | 0.73 ± 0.15 | 0.76 ± 0.19 | .977 (.622) |
| AUC | 3133 ± 1171 | 3035 ± 1197 | 2892 ± 1792 | .829 | .422 | .472 (.104) | 3165 ± 1144 | 3603 ± 1599 | .610 (.301) |
| Lysis time, min | 113.9 ± 33.5 | 115.4 ± 42.2 | 115.4 ± 52.3 | .663 | .291 | .756 (.884) | 122.3 ± 36.6 | 136.9 ± 23.6 | .307 (.192) |