Description of 5 thromboembolic events reported in 4 patients who had undergone surgery
| Reference . | Study type . | Type of hemophilia . | Procedure type . | AICC dose . | TEE . | Notes . |
|---|---|---|---|---|---|---|
| 19 | Observational retrospective | Congenital hemophilia A | Major sigmoidectomy | 104 U/kg per day × 13 d | Non-ST elevation myocardial infarction | |
| 34 | Observational retrospective | Congenital hemophilia A | Hernia repair | 158 U/Kg per day × 7 d | Numerous cerebral infarcts | Patient seemed confused after 6 d from surgery, and at day 7, he was agitated with expressive dysphasia. The symptoms resolved within 2 mo. |
| 38 | Observational prospective | Not reported (congenital or acquired hemophilia A) | Total hip replacement | Not reported | DVT in the brachial vein | Treatment with FEIBA was stopped, and the patient did not receive any specific anticoagulant therapy. Three days later, ultrasonographic analysis revealed that the DVT had resolved, but the SVT persisted. When ultrasonography was repeated 5 d later, no further progression was observed in the SVT, and the swelling had resolved. The patient resumed treatment with FEIBA and did not experience any additional thrombotic complications. |
| SVTs in the basilic and cephalic veins of the left arm | ||||||
| 38 | Observational prospective | Not reported (congenital or acquired hemophilia A) | Moderate-risk surgery | Not reported | Clot in an arteriovenous fistula | In this instance, FEIBA administration was permanently discontinued, and heparin (IV) was administered throughout the night, after which the patient recovered completely. A tranexamic acid-soaked gauze, applied locally to the patient’s hand, was unlikely to have contributed to thrombosis in this instance. |
| Reference . | Study type . | Type of hemophilia . | Procedure type . | AICC dose . | TEE . | Notes . |
|---|---|---|---|---|---|---|
| 19 | Observational retrospective | Congenital hemophilia A | Major sigmoidectomy | 104 U/kg per day × 13 d | Non-ST elevation myocardial infarction | |
| 34 | Observational retrospective | Congenital hemophilia A | Hernia repair | 158 U/Kg per day × 7 d | Numerous cerebral infarcts | Patient seemed confused after 6 d from surgery, and at day 7, he was agitated with expressive dysphasia. The symptoms resolved within 2 mo. |
| 38 | Observational prospective | Not reported (congenital or acquired hemophilia A) | Total hip replacement | Not reported | DVT in the brachial vein | Treatment with FEIBA was stopped, and the patient did not receive any specific anticoagulant therapy. Three days later, ultrasonographic analysis revealed that the DVT had resolved, but the SVT persisted. When ultrasonography was repeated 5 d later, no further progression was observed in the SVT, and the swelling had resolved. The patient resumed treatment with FEIBA and did not experience any additional thrombotic complications. |
| SVTs in the basilic and cephalic veins of the left arm | ||||||
| 38 | Observational prospective | Not reported (congenital or acquired hemophilia A) | Moderate-risk surgery | Not reported | Clot in an arteriovenous fistula | In this instance, FEIBA administration was permanently discontinued, and heparin (IV) was administered throughout the night, after which the patient recovered completely. A tranexamic acid-soaked gauze, applied locally to the patient’s hand, was unlikely to have contributed to thrombosis in this instance. |
DVT, deep vein thrombosis; SVT, superficial vein thrombosis.