Pharmacokinetic characteristics of GSK3277329 in M fascicularis after subcutaneous administration
| Nominal dose . | 0.2 mg/kg (n = 2) . | 1 mg/kg (n = 2) . | 15 mg/kg (n = 3) . |
|---|---|---|---|
| Cmax, ng/mL | 184 (130, 237) | 615 (779, 450) | 6707 ± 1509 |
| Tmax, h | 1.5 (1.0, 2.0) | 0.75 (1.0, 0.5) | 2 |
| t1/2, h | 1.21 (1.13, 1.29) | 1.48 (1.96, 1.00) | 4.35 ± 0.639 |
| AUC0-inf, ng × h/mL | 662 (425, 899) | 2004 (3080, 928) | 44 181 ± 10 251 |
| Nominal dose . | 0.2 mg/kg (n = 2) . | 1 mg/kg (n = 2) . | 15 mg/kg (n = 3) . |
|---|---|---|---|
| Cmax, ng/mL | 184 (130, 237) | 615 (779, 450) | 6707 ± 1509 |
| Tmax, h | 1.5 (1.0, 2.0) | 0.75 (1.0, 0.5) | 2 |
| t1/2, h | 1.21 (1.13, 1.29) | 1.48 (1.96, 1.00) | 4.35 ± 0.639 |
| AUC0-inf, ng × h/mL | 662 (425, 899) | 2004 (3080, 928) | 44 181 ± 10 251 |
Means of 2 animals reported for 0.2- and 1-mg/kg dosed animals. Individual values are listed in parentheses. Means and SD values are reported for the 15-mg/kg dose.
AUC, area under the curve; Cmax, maximum serum concentration; inf, infinity; t1/2, half-life; Tmax, time taken to reach maximum concentration.