Sequences around the scissile peptide bonds of the β-FXIIa substrates FXI and kallikrein and of the β-FXIIa endogenous inhibitors serpin C1, antithrombin, and PAI-1
| . | P4 . | P3 . | P2 . | P1 . | P1′ . | P2′ . | P3′ . | P4′ . | P5′ . |
|---|---|---|---|---|---|---|---|---|---|
| FXI | Ile | Lys | Pro | Arg | Ile | Val | Gly | Gly | Thr |
| Plasma kallikrein | Thr | Ser | Thr | Arg | Ile | Val | Gly | Gly | Thr |
| Serpin C1 | Ser | Val | Ala | Arg | Thr | Leu | Leu | Val | Phe |
| Antithrombin | Ile | Ala | Gly | Arg | Ser | Leu | Asn | Pro | Asn |
| PAI-1 | Val | Ser | Ala | Arg | Met | Ala | Pro | Glu | Glu |
| . | P4 . | P3 . | P2 . | P1 . | P1′ . | P2′ . | P3′ . | P4′ . | P5′ . |
|---|---|---|---|---|---|---|---|---|---|
| FXI | Ile | Lys | Pro | Arg | Ile | Val | Gly | Gly | Thr |
| Plasma kallikrein | Thr | Ser | Thr | Arg | Ile | Val | Gly | Gly | Thr |
| Serpin C1 | Ser | Val | Ala | Arg | Thr | Leu | Leu | Val | Phe |
| Antithrombin | Ile | Ala | Gly | Arg | Ser | Leu | Asn | Pro | Asn |
| PAI-1 | Val | Ser | Ala | Arg | Met | Ala | Pro | Glu | Glu |