Multivariable analyses for DFS, TRM, and relapse
| . | DFS . | TRM . | Relapse . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable . | N . | RR . | 99% CI . | P . | RR . | 99% CI . | P . | RR . | 99% CI . | P . |
| Donor group (main effect) | ||||||||||
| Parous sibling (ref) | 852 | 1.00 | 1.00 | 1.00 | ||||||
| Male URD | 1901 | 1.04 | 0.91-1.19 | .449 | 1.07 | 0.88-1.31 | .380 | 1.03 | 0.87-1.23 | .610 |
| Age at transplant, y | <.0001 | <.0001 | <.0001 | |||||||
| 25-39 (ref) | 669 | 1.00 | 1.00 | 1.00 | ||||||
| 40-49 | 710 | 1.17 | 0.98-1.40 | .022 | 1.32 | 1.01-1.74 | .009 | 1.09 | 0.86-1.37 | .360 |
| 50-59 | 848 | 1.39 | 1.170-1.64 | <.0001 | 1.67 | 1.29-2.17 | <.0001 | 1.27 | 1.02-1.58 | .006 |
| 60+ | 526 | 1.66 | 1.37-2.00 | <.0001 | 2.05 | 1.53-2.75 | <.0001 | 1.53 | 1.19-1.96 | <.0001 |
| Disease | <.0001 | |||||||||
| AML (ref) | 1701 | – | – | – | – | – | – | 1.00 | ||
| ALL | 490 | – | – | – | – | – | – | 0.97 | 0.77-1.21 | .708 |
| MDS | 562 | – | – | – | – | – | – | 0.62 | 0.49-0.77 | <.0001 |
| Karnofsky score at transplant | <.0001 | |||||||||
| ≥90 (ref) | 1662 | 1.00 | 1.00 | – | – | – | ||||
| <90 | 917 | 1.31 | 1.15-1.48 | <.0001 | 1.59 | 1.31-1.92 | <.0001 | – | – | – |
| Missing | 174 | 1.10 | 0.86-1.41 | .308 | 1.11 | 0.75-1.63 | .487 | – | – | – |
| TBI used in conditioning regimen | ||||||||||
| TBI ± others (ref) | 1277 | 1.00 | 1.00 | – | – | – | ||||
| Non-TBI | 1476 | 0.86 | 0.76-0.97 | .002 | 0.83 | 0.69-0.99 | .008 | – | – | – |
| Disease status at transplant | <.0001 | <.0001 | ||||||||
| Early (ref) | 1509 | 1.00 | – | – | – | 1.00 | ||||
| Intermediate | 466 | 1.06 | 0.890-1.26 | .407 | – | – | – | 1.12 | 0.89-1.42 | .198 |
| Advanced | 760 | 1.87 | 1.63-2.14 | <.0001 | – | – | – | 2.57 | 2.15-3.06 | <.0001 |
| Missing | 18 | 1.81 | 0.92-3.56 | .023 | – | – | – | 2.73 | 1.24-6.02 | .001 |
| Year of transplant | .005 | .002 | ||||||||
| 2000-2003 (ref) | 544 | 1.00 | 1.00 | – | – | – | ||||
| 2004-2008 | 1464 | 0.96 | 0.82-1.13 | .534 | 0.85 | 0.68-1.08 | .077 | – | – | – |
| 2009-2012 | 745 | 0.82 | 0.68-0.98 | .004 | 0.68 | 0.52-0.90 | <.001 | – | – | – |
| Time from diagnosis to transplant, mo | .0054 | |||||||||
| <6 (ref) | 1286 | – | – | – | 1.00 | – | – | – | ||
| 6-12 | 702 | – | – | – | 1.35 | 1.08-1.68 | .0004 | – | – | – |
| >12 | 761 | – | – | – | 1.10 | 0.88-1.37 | .2842 | – | – | – |
| Missing | 4 | – | – | – | 1.44 | 0.11-19 | .7165 | – | – | – |
| . | DFS . | TRM . | Relapse . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable . | N . | RR . | 99% CI . | P . | RR . | 99% CI . | P . | RR . | 99% CI . | P . |
| Donor group (main effect) | ||||||||||
| Parous sibling (ref) | 852 | 1.00 | 1.00 | 1.00 | ||||||
| Male URD | 1901 | 1.04 | 0.91-1.19 | .449 | 1.07 | 0.88-1.31 | .380 | 1.03 | 0.87-1.23 | .610 |
| Age at transplant, y | <.0001 | <.0001 | <.0001 | |||||||
| 25-39 (ref) | 669 | 1.00 | 1.00 | 1.00 | ||||||
| 40-49 | 710 | 1.17 | 0.98-1.40 | .022 | 1.32 | 1.01-1.74 | .009 | 1.09 | 0.86-1.37 | .360 |
| 50-59 | 848 | 1.39 | 1.170-1.64 | <.0001 | 1.67 | 1.29-2.17 | <.0001 | 1.27 | 1.02-1.58 | .006 |
| 60+ | 526 | 1.66 | 1.37-2.00 | <.0001 | 2.05 | 1.53-2.75 | <.0001 | 1.53 | 1.19-1.96 | <.0001 |
| Disease | <.0001 | |||||||||
| AML (ref) | 1701 | – | – | – | – | – | – | 1.00 | ||
| ALL | 490 | – | – | – | – | – | – | 0.97 | 0.77-1.21 | .708 |
| MDS | 562 | – | – | – | – | – | – | 0.62 | 0.49-0.77 | <.0001 |
| Karnofsky score at transplant | <.0001 | |||||||||
| ≥90 (ref) | 1662 | 1.00 | 1.00 | – | – | – | ||||
| <90 | 917 | 1.31 | 1.15-1.48 | <.0001 | 1.59 | 1.31-1.92 | <.0001 | – | – | – |
| Missing | 174 | 1.10 | 0.86-1.41 | .308 | 1.11 | 0.75-1.63 | .487 | – | – | – |
| TBI used in conditioning regimen | ||||||||||
| TBI ± others (ref) | 1277 | 1.00 | 1.00 | – | – | – | ||||
| Non-TBI | 1476 | 0.86 | 0.76-0.97 | .002 | 0.83 | 0.69-0.99 | .008 | – | – | – |
| Disease status at transplant | <.0001 | <.0001 | ||||||||
| Early (ref) | 1509 | 1.00 | – | – | – | 1.00 | ||||
| Intermediate | 466 | 1.06 | 0.890-1.26 | .407 | – | – | – | 1.12 | 0.89-1.42 | .198 |
| Advanced | 760 | 1.87 | 1.63-2.14 | <.0001 | – | – | – | 2.57 | 2.15-3.06 | <.0001 |
| Missing | 18 | 1.81 | 0.92-3.56 | .023 | – | – | – | 2.73 | 1.24-6.02 | .001 |
| Year of transplant | .005 | .002 | ||||||||
| 2000-2003 (ref) | 544 | 1.00 | 1.00 | – | – | – | ||||
| 2004-2008 | 1464 | 0.96 | 0.82-1.13 | .534 | 0.85 | 0.68-1.08 | .077 | – | – | – |
| 2009-2012 | 745 | 0.82 | 0.68-0.98 | .004 | 0.68 | 0.52-0.90 | <.001 | – | – | – |
| Time from diagnosis to transplant, mo | .0054 | |||||||||
| <6 (ref) | 1286 | – | – | – | 1.00 | – | – | – | ||
| 6-12 | 702 | – | – | – | 1.35 | 1.08-1.68 | .0004 | – | – | – |
| >12 | 761 | – | – | – | 1.10 | 0.88-1.37 | .2842 | – | – | – |
| Missing | 4 | – | – | – | 1.44 | 0.11-19 | .7165 | – | – | – |