Cytotoxicity of IMGN632 and X-ADC in AML cell lines
| Cell line . | CD123 ABC . | IMGN632 IC50, pM . | X-ADC IC50, pM . | Prognostic marker . |
|---|---|---|---|---|
| EOL-1 | 2600 | 2 | 1 | — |
| HNT-34 | 13 000 | 9 | 4 | EVI1 ↑ |
| KASUMI-3 | 9 000 | 3 | 0.9 | EVI1 ↑, MDR1 |
| KG-1 | 3 500 | 10 | 6 | p53 mut, MDR1 |
| KO52 | 1 200 | 6.6 | 2 | — |
| MOLM-13 | 5 300 | 0.5 | 0.8 | FLT3-ITD |
| MV4-11 | 8 800 | 1 | 0.4 | FLT3-ITD |
| SHI-1 | 4 300 | 5 | 2 | p53 mut |
| SKM-1 | 1 100 | 40 | 40 | p53 mut |
| UCSD-AML1 | 3 200 | 0.6 | 0.2 | EVI1 ↑ |
| Namalwa (B-cell lymphoma) | 0 | 10 000 | 8000 | — |
| Cell line . | CD123 ABC . | IMGN632 IC50, pM . | X-ADC IC50, pM . | Prognostic marker . |
|---|---|---|---|---|
| EOL-1 | 2600 | 2 | 1 | — |
| HNT-34 | 13 000 | 9 | 4 | EVI1 ↑ |
| KASUMI-3 | 9 000 | 3 | 0.9 | EVI1 ↑, MDR1 |
| KG-1 | 3 500 | 10 | 6 | p53 mut, MDR1 |
| KO52 | 1 200 | 6.6 | 2 | — |
| MOLM-13 | 5 300 | 0.5 | 0.8 | FLT3-ITD |
| MV4-11 | 8 800 | 1 | 0.4 | FLT3-ITD |
| SHI-1 | 4 300 | 5 | 2 | p53 mut |
| SKM-1 | 1 100 | 40 | 40 | p53 mut |
| UCSD-AML1 | 3 200 | 0.6 | 0.2 | EVI1 ↑ |
| Namalwa (B-cell lymphoma) | 0 | 10 000 | 8000 | — |
—, No known prognostic markers were present.