Patient characteristics by treatment group
| . | Platelets (n = 137) . | No platelets (n = 124) . | P . |
|---|---|---|---|
| Age, median (IQR), y | 35 (25-50) | 35 (26-49.5) | .82 |
| Male sex, n (%) | 109 (79.6) | 103 (83.1) | .53 |
| Race, n (%) | .78 | ||
| White | 88 (64.2) | 77 (62.1) | |
| Black | 35 (25.6) | 36 (29.0) | |
| Other | 14 (10.2) | 11 (8.9) | |
| Glasgow Coma Scale score, median (IQR) | 14 (3-15) | 14 (3-15) | .28 |
| Systolic blood pressure, mm Hg | |||
| Median (IQR) | 102 (85-123) | 105 (80-126) | .56 |
| ≤90, n (%) | 51 (37.8) | 51 (42.9) | .44 |
| Diastolic blood pressure, median (IQR), mm Hg | 72 (57-89) | 65 (50-89) | .10 |
| Heart rate, beats per min | |||
| Median (IQR) | 110 (93-130) | 103 (87-125) | .07 |
| ≥120, n (%) | 52 (38.0) | 41 (33.1) | .44 |
| Respiratory rate, median (IQR), breaths per min | 20 (16-25) | 21 (18-26) | .25 |
| Blood consumption score ≥2, n (%) | 83 (60.6) | 78 (62.9) | .71 |
| Critical administration threshold, N (%) | 66 (48.2) | 65 (52.4) | .54 |
| Mechanism of injury, n (%) | |||
| Any blunt injury | 70 (51.1) | 57 (46.0) | .46 |
| Any penetrating injury | 70 (51.1) | 67 (54.0) | .71 |
| Time to randomization, median (IQR), min | 35 (20-54) | 27.5 (18-43) | .01 |
| Hemoglobin level, g/dL | |||
| Median (IQR) | 12.6 (11.1-13.7) | 12.7 (10.6-13.7) | .49 |
| ≤11, n (%) | 33 (24.1) | 34 (27.4) | .30 |
| >11, n (%) | 100 (73.0) | 82 (66.1) | |
| Unknown, n (%) | 4 (2.9) | 8 (6.5) | |
| INR | |||
| Median (IQR) | 1.20 (1.10-1.32) | 1.20 (1.14-1.40) | .18 |
| >1.5, n (%) | 12 (8.8) | 11 (8.9) | .66 |
| ≤1.5, n (%) | 78 (56.9) | 64 (51.6) | |
| Unknown, n (%) | 47 (34.3) | 49 (39.5) | |
| Thromboelastography R time, min | |||
| Median (IQR) | 3.6 (2.8-4.4) | 3.9 (2.8-4.7) | .31 |
| >8, n (%) | 6 (4.4) | 4 (3.2) | .94 |
| ≤8, n (%) | 101 (73.7) | 92 (74.2) | |
| Unknown, n (%) | 30 (21.9) | 28 (22.6) | |
| Platelet count, ×109/L | |||
| Median (IQR) | 244 (195-297) | 243 (184-285) | .60 |
| <150, n (%) | 10 (7.3) | 14 (11.3) | .17 |
| <100, n (%) | 3 (2.2) | 2 (1.6) | .33 |
| <50, n (%) | 0 (0) | 0 (0) | |
| Unknown, n (%) | 6 (4.4) | 11 (8.9) | |
| Base excess, median (IQR), mmol/L | −6.1 (−9.8 to −2.9) | −6.8 (−11.3 to −3.0) | .40 |
| Injury Severity Score, median (IQR) | 22 (14-34) | 21.5 (11-29.5) | .15 |
| AIS Head score ≥3, n (%) | 22 (16.1) | 18 (14.5) | .86 |
| Revised Trauma Score, median (IQR) | 7.11 (4.09-7.84) | 6.90 (4.09-7.84) | .28 |
| . | Platelets (n = 137) . | No platelets (n = 124) . | P . |
|---|---|---|---|
| Age, median (IQR), y | 35 (25-50) | 35 (26-49.5) | .82 |
| Male sex, n (%) | 109 (79.6) | 103 (83.1) | .53 |
| Race, n (%) | .78 | ||
| White | 88 (64.2) | 77 (62.1) | |
| Black | 35 (25.6) | 36 (29.0) | |
| Other | 14 (10.2) | 11 (8.9) | |
| Glasgow Coma Scale score, median (IQR) | 14 (3-15) | 14 (3-15) | .28 |
| Systolic blood pressure, mm Hg | |||
| Median (IQR) | 102 (85-123) | 105 (80-126) | .56 |
| ≤90, n (%) | 51 (37.8) | 51 (42.9) | .44 |
| Diastolic blood pressure, median (IQR), mm Hg | 72 (57-89) | 65 (50-89) | .10 |
| Heart rate, beats per min | |||
| Median (IQR) | 110 (93-130) | 103 (87-125) | .07 |
| ≥120, n (%) | 52 (38.0) | 41 (33.1) | .44 |
| Respiratory rate, median (IQR), breaths per min | 20 (16-25) | 21 (18-26) | .25 |
| Blood consumption score ≥2, n (%) | 83 (60.6) | 78 (62.9) | .71 |
| Critical administration threshold, N (%) | 66 (48.2) | 65 (52.4) | .54 |
| Mechanism of injury, n (%) | |||
| Any blunt injury | 70 (51.1) | 57 (46.0) | .46 |
| Any penetrating injury | 70 (51.1) | 67 (54.0) | .71 |
| Time to randomization, median (IQR), min | 35 (20-54) | 27.5 (18-43) | .01 |
| Hemoglobin level, g/dL | |||
| Median (IQR) | 12.6 (11.1-13.7) | 12.7 (10.6-13.7) | .49 |
| ≤11, n (%) | 33 (24.1) | 34 (27.4) | .30 |
| >11, n (%) | 100 (73.0) | 82 (66.1) | |
| Unknown, n (%) | 4 (2.9) | 8 (6.5) | |
| INR | |||
| Median (IQR) | 1.20 (1.10-1.32) | 1.20 (1.14-1.40) | .18 |
| >1.5, n (%) | 12 (8.8) | 11 (8.9) | .66 |
| ≤1.5, n (%) | 78 (56.9) | 64 (51.6) | |
| Unknown, n (%) | 47 (34.3) | 49 (39.5) | |
| Thromboelastography R time, min | |||
| Median (IQR) | 3.6 (2.8-4.4) | 3.9 (2.8-4.7) | .31 |
| >8, n (%) | 6 (4.4) | 4 (3.2) | .94 |
| ≤8, n (%) | 101 (73.7) | 92 (74.2) | |
| Unknown, n (%) | 30 (21.9) | 28 (22.6) | |
| Platelet count, ×109/L | |||
| Median (IQR) | 244 (195-297) | 243 (184-285) | .60 |
| <150, n (%) | 10 (7.3) | 14 (11.3) | .17 |
| <100, n (%) | 3 (2.2) | 2 (1.6) | .33 |
| <50, n (%) | 0 (0) | 0 (0) | |
| Unknown, n (%) | 6 (4.4) | 11 (8.9) | |
| Base excess, median (IQR), mmol/L | −6.1 (−9.8 to −2.9) | −6.8 (−11.3 to −3.0) | .40 |
| Injury Severity Score, median (IQR) | 22 (14-34) | 21.5 (11-29.5) | .15 |
| AIS Head score ≥3, n (%) | 22 (16.1) | 18 (14.5) | .86 |
| Revised Trauma Score, median (IQR) | 7.11 (4.09-7.84) | 6.90 (4.09-7.84) | .28 |
Associations between characteristics and treatment were evaluated using the Wilcoxon rank sum test for continuous variables and Fisher’s exact test for categorical variables. All laboratory values were drawn on admission.
AIS, Abbreviated Injury Scale; INR, international normalized ratio.