Table 2.

Reported menorrhagia and treatment received prior to diagnosis with low VWF

MenorrhagiaLoVIC, n (% of all female enrollees)
Total cohort 120 
 Self-reported menorrhagia 107/120 (89.2) 
Symptoms  
 Changing pads/tampons >2 hourly 92 (76.6) 
 Bleeding >7 d 69 (57.5) 
 Clots and flooding 104 (86.6) 
Medical consultation  
 Consultation 73 (60.8) 
 Iron therapy 39 (32.5) 
 Antifibrinolytic 23 (19.2) 
 Hormonal therapy 47 (39.2) 
 Combined hormonal and antifibrinolytics 8 (6.6) 
 Intrauterine levonorgestrel-releasing device 20 (16.7) 
 Dilatation and curettage 23 (19.2) 
 Endometrial ablation 5 (4.2) 
 Hysterectomy 9 (7.5) 
 Treatment with desmopressin 1 (0.8) 
 Treatment with plasma/platelets/factor concentrate 
 Red blood cell transfusion 2 (1.7) 
 Hospital admission and emergency treatment 2 (1.7) 
Duration of symptoms  
 Symptoms since menarche 84 (70.0) 
 >2 d off school/work per year 47 (39.2) 
 Menorrhagia >12 mo 21 (17.5) 
MenorrhagiaLoVIC, n (% of all female enrollees)
Total cohort 120 
 Self-reported menorrhagia 107/120 (89.2) 
Symptoms  
 Changing pads/tampons >2 hourly 92 (76.6) 
 Bleeding >7 d 69 (57.5) 
 Clots and flooding 104 (86.6) 
Medical consultation  
 Consultation 73 (60.8) 
 Iron therapy 39 (32.5) 
 Antifibrinolytic 23 (19.2) 
 Hormonal therapy 47 (39.2) 
 Combined hormonal and antifibrinolytics 8 (6.6) 
 Intrauterine levonorgestrel-releasing device 20 (16.7) 
 Dilatation and curettage 23 (19.2) 
 Endometrial ablation 5 (4.2) 
 Hysterectomy 9 (7.5) 
 Treatment with desmopressin 1 (0.8) 
 Treatment with plasma/platelets/factor concentrate 
 Red blood cell transfusion 2 (1.7) 
 Hospital admission and emergency treatment 2 (1.7) 
Duration of symptoms  
 Symptoms since menarche 84 (70.0) 
 >2 d off school/work per year 47 (39.2) 
 Menorrhagia >12 mo 21 (17.5) 
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