Table 1. Clinical features and death of... | American Society of Hematology

Table 1.

Clinical features and death of patients with TTP, 1925-2017

Clinical feature	1925-1964¹	1964-1980⁶	1982-1989⁷	1995-2017¹²
No. of patients	271	275	102	89
Diagnostic criteria, %
Thrombocytopenia	96	96	100	100
Hemolytic anemia	96	98	100	100
Neurologic symptoms	92	84	71	64
Kidney injury	88	76	59	25
Fever	98	59	26	10
Survival, %	10	46	78	87

Clinical feature	1925-1964¹	1964-1980⁶	1982-1989⁷	1995-2017¹²
No. of patients	271	275	102	89
Diagnostic criteria, %
Thrombocytopenia	96	96	100	100
Hemolytic anemia	96	98	100	100
Neurologic symptoms	92	84	71	64
Kidney injury	88	76	59	25
Fever	98	59	26	10
Survival, %	10	46	78	87

The data in these 4 reports^1,6,7,12 illustrate the trends of clinical features and survival. They are not completely comparable. The earlier observations^1,6 represent data from both the initial presentation and hospital course, which was often prolonged in the era before effective treatment. In the 2 more recent studies,^7,12 thrombocytopenia and microangiopathic hemolytic anemia were required abnormalities for establishing the diagnosis of TTP. In the most recent data, fever was recorded only if it was accompanied by chills.¹²

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