Table 2. Summary of the most important... | American Society of Hematology

Table 2.

Summary of the most important variables to predict GVHD and NRM in univariate analysis

Variable	Polymorphism	D/R	OR*
Variable	Polymorphism	D/R	aGVHD 2-4	aGVHD 3-4	cGVHD	Extensive cGVHD	NRM
Clinical
Recipient age >45 y					H	H
Recipient sex, male vs female						H
Female donor/male recipient							H
MDS					H
Conditioning, RIC vs MAC					H	H
Conditioning regimen, no TBI vs TBI				H
Stem-cell source, PB vs BM					H	H
aGVHD, grade 2-4					H	H
Genetic
IL-1A	rs1800587	D			H
IL-1B	rs1143627	R	H
		D			L
	rs16944	R	H
		D			H
	rs1143634	R			H
		D			H
IL-2	rs2069762	R				H
IL-6	rs1800795	R		H
IL-17A	rs8193036	D	H
	rs4711998	R	H			H
		D				H
	rs2275913	R					H
	rs3819024	D					L
		R					L
IL-23R	rs6687620	R			H	H
		D				H
	rs11209026	R			H
TGFβ	rs1800469	D				H
INF-γ	rs2069705	R			H

Variable	Polymorphism	D/R	OR*
Variable	Polymorphism	D/R	aGVHD 2-4	aGVHD 3-4	cGVHD	Extensive cGVHD	NRM
Clinical
Recipient age >45 y					H	H
Recipient sex, male vs female						H
Female donor/male recipient							H
MDS					H
Conditioning, RIC vs MAC					H	H
Conditioning regimen, no TBI vs TBI				H
Stem-cell source, PB vs BM					H	H
aGVHD, grade 2-4					H	H
Genetic
IL-1A	rs1800587	D			H
IL-1B	rs1143627	R	H
		D			L
	rs16944	R	H
		D			H
	rs1143634	R			H
		D			H
IL-2	rs2069762	R				H
IL-6	rs1800795	R		H
IL-17A	rs8193036	D	H
	rs4711998	R	H			H
		D				H
	rs2275913	R					H
	rs3819024	D					L
		R					L
IL-23R	rs6687620	R			H	H
		D				H
	rs11209026	R			H
TGFβ	rs1800469	D				H
INF-γ	rs2069705	R			H

All variables are statistically significant (P < .05).

BM, bone marrow; D, donor; H, higher risk; L, lower risk; MAC, myeloablative conditioning; OR, odds ratio; PB, peripheral blood; R, recipient; RIC, reduced-intensity conditioning.

OR = 1 (neutral); OR < 1 (L); OR > 1 (H).

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