LASSO multivariate analysis of the association between genetic variables and GVHD/NRM
| Genetic variable . | Polymorphism . | Genotype . | D/R . | Model of transmission . | OR* . | ||||
|---|---|---|---|---|---|---|---|---|---|
| aGVHD 2-4 . | aGVHD 3-4 . | cGVHD . | Extensive cGVHD . | NRM . | |||||
| IL-1A | rs1800587 | CT | D | Cod | 0.750 | 1.383 | |||
| IL-1B | rs1143627 | TT | R | Dom | 0.809 | ||||
| CT | R | Cod | 1.037 | ||||||
| TT | D | Dom | 1.472 | 1.135 | |||||
| TT | D | Cod | 1.113 | ||||||
| CC<CT<TT | R | Add | 0.95 | ||||||
| CC<CT<TT | D | Add | 1.202 | 1.060 | |||||
| rs16944 | GG | R | Dom | 0.893 | |||||
| CC | D | Dom | 1.020 | ||||||
| AA<AG<GG | D | Add | 1.128 | ||||||
| rs1143634 | CC | R | Dom | 0.831 | 0.847 | ||||
| CC | R | Cod | 0.952 | 0.987 | |||||
| TT<CT<CC | R | Add | 0.993 | ||||||
| TT | D | Rec | 2.763 | 1.071 | 1.604 | 0.681 | |||
| TT<CT<CC | D | Add | 0.747 | ||||||
| IL-2 | rs2069762 | GG | R | Rec | 0.278 | 0.329 | 0.795 | 0.904 | |
| GT | R | Cod | 1.153 | 1.014 | |||||
| GG<GT<TT | D | Add | 0.736 | 1.032 | |||||
| IL-6 | rs1800795 | GG | R | Dom | 1.471 | ||||
| GG | R | Cod | 0.587 | 0.758 | |||||
| CC | R | Rec | 0.768 | ||||||
| CG | R | Cod | 1.025 | ||||||
| GG | D | Dom | 0.877 | ||||||
| CC | D | Rec | 0.922 | ||||||
| IL-7R | rs1494555 | CT | R | Cod | 1.316 | ||||
| CC | R | Rec | 1.703 | ||||||
| CT | D | Cod | 0.813 | 1.596 | 0.843 | ||||
| TT | D | Dom | 1.071 | ||||||
| CC<CT<TT | D | Add | 1.166 | ||||||
| IL-10 | rs1800871 | TT | R | Rec | 0.702 | ||||
| CT | R | Cod | 3.351 | 1.374 | |||||
| CT | D | Cod | 1.124 | ||||||
| TT | D | Rec | 1.019 | ||||||
| TT<CT<CC | D | Add | 1.104 | ||||||
| rs1800872 | AC | R | Cod | 1.004 | |||||
| AA | D | Rec | 1.005 | ||||||
| rs1800896 | AG | R | Cod | 1.246 | |||||
| AG | D | Cod | 1.139 | ||||||
| GG<AG<AA | D | Add | 0.794 | 0.953 | |||||
| GG | D | Rec | 1.419 | ||||||
| IL-17A | rs8193036 | CC | R | Rec | 1.397 | 2.395 | 1.329 | ||
| CT | R | Cod | 0.919 | 0.903 | |||||
| CC<CT<TT | R | Add | 0.833 | ||||||
| CC | D | Rec | .,419 | 2.677 | |||||
| CC<CT<TT | D | Add | 0.858 | ||||||
| CT | D | Cod | 0.705 | ||||||
| rs3819024 | AA | R | Dom | 1.149 | 1.254 | ||||
| GG | R | Cod | 1.002 | ||||||
| AG | R | Cod | 0.747 | ||||||
| GG | R | Rec | 0.869 | ||||||
| GG | D | Rec | 1.126 | 1.386 | |||||
| rs4711998 | AG | R | Cod | 1.092 | 1.071 | ||||
| GG | R | Cod | 0.990 | ||||||
| AA | R | Rec | 0.746 | ||||||
| GG | R | Dom | 0.712 | ||||||
| AA<AG<GG | D | Add | 0.837 | ||||||
| GG | D | Dom | 0.894 | 0.674 | |||||
| AG | D | Cod | 1.377 | 1.013 | |||||
| GG | D | Cod | 0.918 | ||||||
| rs2275913 | AG | R | Cod | 1.340 | |||||
| AA<AG<GG | R | Add | 0.835 | ||||||
| AA | R | Rec | 0.077 | 1.617 | |||||
| AA | D | Rec | 1.424 | 1.446 | |||||
| IL-17F | rs763780 | TT | R | Dom | 0.723 | ||||
| IL-23R | rs6687620 | TT | R | Rec | 0.539 | 8.736 | |||
| CC | R | Dom | 0.564 | ||||||
| TT<CT<CC | R | Add | 1.620 | ||||||
| TT | D | Rec | 0.691 | 3.402 | 1.013 | 1.661 | |||
| TT<CT<CC | D | Add | 1.358 | 0.639 | |||||
| CT | D | Cod | 0.514 | ||||||
| rs11209026 | GG | R | Dom | 0.495 | 0.994 | 1.740 | |||
| AA<AG<GG | R | Add | 0.776 | 0.943 | |||||
| AA | D | Rec | 0.181 | 1.740 | |||||
| AG | D | Cod | 1.110 | ||||||
| AA<AG<GG | D | Add | 1.030 | ||||||
| INF-γ | rs2430561 | AT | R | Cod | 1.537 | 0.806 | |||
| AA<AT<TT | R | Add | 0.958 | ||||||
| AA | R | Rec | 1.778 | ||||||
| AT | D | Cod | 0.771 | ||||||
| rs2069705 | CT | R | Cod | 0.641 | 0.755 | 0.966 | |||
| TT | R | Rec | 1.114 | ||||||
| CT | D | Dom | 0.880 | ||||||
| TT<CT<CC | D | Cod | 1.296 | ||||||
| CT | D | Add | 0.810 | ||||||
| TGFβ | rs2241716 | AA<AG<GG | R | Add | 0.990 | ||||
| GG | R | Dom | 0.979 | ||||||
| GG | D | Dom | 0.359 | 0.154 | |||||
| AA<AG<GG | D | Add | 0.667 | ||||||
| rs1800469 | TT | R | Rec | 1.566 | 3.320 | ||||
| CC | R | Dom | 0.875 | ||||||
| TT<CT<CC | R | Add | 0.994 | ||||||
| CT | D | Cod | 1.008 | 0.956 | |||||
| TT | D | Rec | 0.280 | 0.722 | |||||
| TT<CT<CC | D | Add | 1.101 | ||||||
| TNFα | rs1799964 | CC | R | Rec | 0.968 | ||||
| TT | R | Dom | 1.237 | ||||||
| CC | D | Rec | 1.556 | ||||||
| CC<CT<TT | D | Add | 0.939 | ||||||
| rs1800629 | AG | R | Cod | 2.820 | |||||
| AA | D | Rec | 0.938 | ||||||
| rs1800610 | AA | R | Rec | 0.807 | 0.632 | ||||
| AA<AG<GG | R | Add | 1.128 | ||||||
| TT | R | Rec | 8.854 | ||||||
| AA<AG<GG | D | Add | 1.139 | ||||||
| TT | D | Rec | 0.751 | ||||||
| Genetic variable . | Polymorphism . | Genotype . | D/R . | Model of transmission . | OR* . | ||||
|---|---|---|---|---|---|---|---|---|---|
| aGVHD 2-4 . | aGVHD 3-4 . | cGVHD . | Extensive cGVHD . | NRM . | |||||
| IL-1A | rs1800587 | CT | D | Cod | 0.750 | 1.383 | |||
| IL-1B | rs1143627 | TT | R | Dom | 0.809 | ||||
| CT | R | Cod | 1.037 | ||||||
| TT | D | Dom | 1.472 | 1.135 | |||||
| TT | D | Cod | 1.113 | ||||||
| CC<CT<TT | R | Add | 0.95 | ||||||
| CC<CT<TT | D | Add | 1.202 | 1.060 | |||||
| rs16944 | GG | R | Dom | 0.893 | |||||
| CC | D | Dom | 1.020 | ||||||
| AA<AG<GG | D | Add | 1.128 | ||||||
| rs1143634 | CC | R | Dom | 0.831 | 0.847 | ||||
| CC | R | Cod | 0.952 | 0.987 | |||||
| TT<CT<CC | R | Add | 0.993 | ||||||
| TT | D | Rec | 2.763 | 1.071 | 1.604 | 0.681 | |||
| TT<CT<CC | D | Add | 0.747 | ||||||
| IL-2 | rs2069762 | GG | R | Rec | 0.278 | 0.329 | 0.795 | 0.904 | |
| GT | R | Cod | 1.153 | 1.014 | |||||
| GG<GT<TT | D | Add | 0.736 | 1.032 | |||||
| IL-6 | rs1800795 | GG | R | Dom | 1.471 | ||||
| GG | R | Cod | 0.587 | 0.758 | |||||
| CC | R | Rec | 0.768 | ||||||
| CG | R | Cod | 1.025 | ||||||
| GG | D | Dom | 0.877 | ||||||
| CC | D | Rec | 0.922 | ||||||
| IL-7R | rs1494555 | CT | R | Cod | 1.316 | ||||
| CC | R | Rec | 1.703 | ||||||
| CT | D | Cod | 0.813 | 1.596 | 0.843 | ||||
| TT | D | Dom | 1.071 | ||||||
| CC<CT<TT | D | Add | 1.166 | ||||||
| IL-10 | rs1800871 | TT | R | Rec | 0.702 | ||||
| CT | R | Cod | 3.351 | 1.374 | |||||
| CT | D | Cod | 1.124 | ||||||
| TT | D | Rec | 1.019 | ||||||
| TT<CT<CC | D | Add | 1.104 | ||||||
| rs1800872 | AC | R | Cod | 1.004 | |||||
| AA | D | Rec | 1.005 | ||||||
| rs1800896 | AG | R | Cod | 1.246 | |||||
| AG | D | Cod | 1.139 | ||||||
| GG<AG<AA | D | Add | 0.794 | 0.953 | |||||
| GG | D | Rec | 1.419 | ||||||
| IL-17A | rs8193036 | CC | R | Rec | 1.397 | 2.395 | 1.329 | ||
| CT | R | Cod | 0.919 | 0.903 | |||||
| CC<CT<TT | R | Add | 0.833 | ||||||
| CC | D | Rec | .,419 | 2.677 | |||||
| CC<CT<TT | D | Add | 0.858 | ||||||
| CT | D | Cod | 0.705 | ||||||
| rs3819024 | AA | R | Dom | 1.149 | 1.254 | ||||
| GG | R | Cod | 1.002 | ||||||
| AG | R | Cod | 0.747 | ||||||
| GG | R | Rec | 0.869 | ||||||
| GG | D | Rec | 1.126 | 1.386 | |||||
| rs4711998 | AG | R | Cod | 1.092 | 1.071 | ||||
| GG | R | Cod | 0.990 | ||||||
| AA | R | Rec | 0.746 | ||||||
| GG | R | Dom | 0.712 | ||||||
| AA<AG<GG | D | Add | 0.837 | ||||||
| GG | D | Dom | 0.894 | 0.674 | |||||
| AG | D | Cod | 1.377 | 1.013 | |||||
| GG | D | Cod | 0.918 | ||||||
| rs2275913 | AG | R | Cod | 1.340 | |||||
| AA<AG<GG | R | Add | 0.835 | ||||||
| AA | R | Rec | 0.077 | 1.617 | |||||
| AA | D | Rec | 1.424 | 1.446 | |||||
| IL-17F | rs763780 | TT | R | Dom | 0.723 | ||||
| IL-23R | rs6687620 | TT | R | Rec | 0.539 | 8.736 | |||
| CC | R | Dom | 0.564 | ||||||
| TT<CT<CC | R | Add | 1.620 | ||||||
| TT | D | Rec | 0.691 | 3.402 | 1.013 | 1.661 | |||
| TT<CT<CC | D | Add | 1.358 | 0.639 | |||||
| CT | D | Cod | 0.514 | ||||||
| rs11209026 | GG | R | Dom | 0.495 | 0.994 | 1.740 | |||
| AA<AG<GG | R | Add | 0.776 | 0.943 | |||||
| AA | D | Rec | 0.181 | 1.740 | |||||
| AG | D | Cod | 1.110 | ||||||
| AA<AG<GG | D | Add | 1.030 | ||||||
| INF-γ | rs2430561 | AT | R | Cod | 1.537 | 0.806 | |||
| AA<AT<TT | R | Add | 0.958 | ||||||
| AA | R | Rec | 1.778 | ||||||
| AT | D | Cod | 0.771 | ||||||
| rs2069705 | CT | R | Cod | 0.641 | 0.755 | 0.966 | |||
| TT | R | Rec | 1.114 | ||||||
| CT | D | Dom | 0.880 | ||||||
| TT<CT<CC | D | Cod | 1.296 | ||||||
| CT | D | Add | 0.810 | ||||||
| TGFβ | rs2241716 | AA<AG<GG | R | Add | 0.990 | ||||
| GG | R | Dom | 0.979 | ||||||
| GG | D | Dom | 0.359 | 0.154 | |||||
| AA<AG<GG | D | Add | 0.667 | ||||||
| rs1800469 | TT | R | Rec | 1.566 | 3.320 | ||||
| CC | R | Dom | 0.875 | ||||||
| TT<CT<CC | R | Add | 0.994 | ||||||
| CT | D | Cod | 1.008 | 0.956 | |||||
| TT | D | Rec | 0.280 | 0.722 | |||||
| TT<CT<CC | D | Add | 1.101 | ||||||
| TNFα | rs1799964 | CC | R | Rec | 0.968 | ||||
| TT | R | Dom | 1.237 | ||||||
| CC | D | Rec | 1.556 | ||||||
| CC<CT<TT | D | Add | 0.939 | ||||||
| rs1800629 | AG | R | Cod | 2.820 | |||||
| AA | D | Rec | 0.938 | ||||||
| rs1800610 | AA | R | Rec | 0.807 | 0.632 | ||||
| AA<AG<GG | R | Add | 1.128 | ||||||
| TT | R | Rec | 8.854 | ||||||
| AA<AG<GG | D | Add | 1.139 | ||||||
| TT | D | Rec | 0.751 | ||||||
Add, additive; Cod, codominant; Dom, dominant; Rec, recessive.
Values (OR) for the variables were selected by the LASSO procedure (described in “Methods”).
OR values for the variables selected by the LASSO procedure (described in “Methods”). OR values were obtained with the exponential function of β coefficient, which compares the strength of the effect of each individual independent variable with the dependent variable. The higher the absolute value of β, the stronger the effect. β = 0, OR = 1 (neutral); β < 0, OR < 1 (L); β > 0, OR > 1 (H).