Table 1. Characteristics of the study... | American Society of Hematology

Table 1.

Characteristics of the study cohorts

Cohort	City of Hope, N = 1828	Fred Hutchinson Cancer Research Center, N = 580
Population	Single US center; underwent a first HCT between 1 January 1995 and 31 December 2004; alive at 1-y post HCT; no history of CVD prior to HCT; follow-up censor date December 2012	Single US center; underwent any HCT between 1 January 1970 and 31 December 2010; alive at 1-y post-HCT; no history of CVD prior to HCT; follow-up censor date December 2012
Study design	Retrospective cohort	Retrospective case cohort
Cancer treatment information	Cumulative chemotherapy doses, radiotherapy fields and doses, no organ-specific dosimetry	Cumulative chemotherapy doses, radiotherapy fields and doses, no organ-specific dosimetry
Cardiovascular disease definition	Medical and death records; limited to CVD occurring ≥1 y post-HCT; heart failure (N = 92),* coronary artery disease (myocardial infarction, symptomatic coronary artery stenosis requiring intervention [N = 43])	Self-report†, hospital registry, medical, and death records; limited to CVD occurring ≥1 y post-HCT; heart failure (N = 56),* coronary artery disease (myocardial infarction, symptomatic coronary artery stenosis requiring intervention [N = 99])

Cohort	City of Hope, N = 1828	Fred Hutchinson Cancer Research Center, N = 580
Population	Single US center; underwent a first HCT between 1 January 1995 and 31 December 2004; alive at 1-y post HCT; no history of CVD prior to HCT; follow-up censor date December 2012	Single US center; underwent any HCT between 1 January 1970 and 31 December 2010; alive at 1-y post-HCT; no history of CVD prior to HCT; follow-up censor date December 2012
Study design	Retrospective cohort	Retrospective case cohort
Cancer treatment information	Cumulative chemotherapy doses, radiotherapy fields and doses, no organ-specific dosimetry	Cumulative chemotherapy doses, radiotherapy fields and doses, no organ-specific dosimetry
Cardiovascular disease definition	Medical and death records; limited to CVD occurring ≥1 y post-HCT; heart failure (N = 92),* coronary artery disease (myocardial infarction, symptomatic coronary artery stenosis requiring intervention [N = 43])	Self-report†, hospital registry, medical, and death records; limited to CVD occurring ≥1 y post-HCT; heart failure (N = 56),* coronary artery disease (myocardial infarction, symptomatic coronary artery stenosis requiring intervention [N = 99])

CVD, cardiovascular disease; HCT, hematopoietic cell transplantation.

Defined per the American Heart Association/American College of Cardiology guidelines.⁵⁹

Patients with self-reported CVD were reviewed against available hospital registry, medical, and death records prior to inclusion.