Multivariable regression analysis with associated hazard ratios for CVD, 95% confidence intervals, integer risk scores, and corresponding prediction models
| Variable . | Hazard ratio . | 95% confidence interval . | P . | Risk score* . | |
|---|---|---|---|---|---|
| Age, y | |||||
| <30 | 1.0 | 0 | |||
| 30 to <50 | 2.35 | 1.15 | 4.80 | .019 | 2 |
| ≥50 y | 4.00 | 1.98 | 8.08 | <.001 | 3 |
| Anthracycline dose | |||||
| ≤250 mg/m2 | 1.0 | 0 | |||
| >250 mg/m2 | 1.88 | 1.33 | 2.66 | <.001 | 1 |
| Hypertension | |||||
| No | 1.0 | 0 | |||
| Yes | 2.03 | 1.42 | 2.90 | <.001 | 2 |
| Diabetes | |||||
| No | 1.0 | 0 | |||
| Yes | 2.70 | 1.84 | 3.97 | <.001 | 2 |
| Smoking | |||||
| Never | 1.0 | 0 | |||
| Ever | 1.39 | 0.99 | 1.96 | .060 | 1 |
| Chest radiation | |||||
| None | 1.0 | 0 | |||
| Any | 1.92 | 1.07 | 3.43 | .028 | 1 |
| Variable . | Hazard ratio . | 95% confidence interval . | P . | Risk score* . | |
|---|---|---|---|---|---|
| Age, y | |||||
| <30 | 1.0 | 0 | |||
| 30 to <50 | 2.35 | 1.15 | 4.80 | .019 | 2 |
| ≥50 y | 4.00 | 1.98 | 8.08 | <.001 | 3 |
| Anthracycline dose | |||||
| ≤250 mg/m2 | 1.0 | 0 | |||
| >250 mg/m2 | 1.88 | 1.33 | 2.66 | <.001 | 1 |
| Hypertension | |||||
| No | 1.0 | 0 | |||
| Yes | 2.03 | 1.42 | 2.90 | <.001 | 2 |
| Diabetes | |||||
| No | 1.0 | 0 | |||
| Yes | 2.70 | 1.84 | 3.97 | <.001 | 2 |
| Smoking | |||||
| Never | 1.0 | 0 | |||
| Ever | 1.39 | 0.99 | 1.96 | .060 | 1 |
| Chest radiation | |||||
| None | 1.0 | 0 | |||
| Any | 1.92 | 1.07 | 3.43 | .028 | 1 |
Risk scores of 0, 1, 2, and 3 correspond to hazard ratios of <1.3, 1.3 to 1.9, 2.0 to 2.9, and 3.0 to 4.9, respectively.