DLT: tinnitus and hearing impairment
| Valproate dose, mg/kg per day . | N . | Tinnitus . | Hearing impairment by audiogram . | ||
|---|---|---|---|---|---|
| Grade 1 . | Grade 3 . | Grade 1 . | Grade 3 . | ||
| 30 | 3 | — | — | — | — |
| 60 | 20 | 4 | — | 1 | — |
| 80 | 3 | 2 | — | 1 | — |
| 100 | 6 | 1 | 1 | — | 1 |
| 120 | 1 | NA | NA | NA | NA |
| Valproate dose, mg/kg per day . | N . | Tinnitus . | Hearing impairment by audiogram . | ||
|---|---|---|---|---|---|
| Grade 1 . | Grade 3 . | Grade 1 . | Grade 3 . | ||
| 30 | 3 | — | — | — | — |
| 60 | 20 | 4 | — | 1 | — |
| 80 | 3 | 2 | — | 1 | — |
| 100 | 6 | 1 | 1 | — | 1 |
| 120 | 1 | NA | NA | NA | NA |
Grading according to CTCAE v4.03.
NA, not applicable.