AREG, Minnesota risk score, and clinical outcomes: multivariate regression
| Factor . | N . | OR of CR/PR . | 95% CI . | P . | Hazard ratio of 2-y OS . | 95% CI . | P . | Hazard ratio of 2-y NRM . | 95% CI . | P . |
|---|---|---|---|---|---|---|---|---|---|---|
| Minnesota risk/AREG | ||||||||||
| SR, low AREG | 102 | 1.00* | 1.00* | 1.00* | ||||||
| SR, high AREG | 92 | 0.41 | 0.20-0.84 | .02 | 2.30 | 1.48-3.58 | <.01 | 3.62 | 1.93-6.78 | <.01 |
| HR, low AREG | 18 | 0.89 | 0.22-3.61 | .87 | 1.44 | 0.63-3.30 | .39 | 1.14 | 0.23-5.62 | .87 |
| HR, high AREG | 39 | 0.18 | 0.08-0.44 | <.01 | 3.35 | 1.94-5.79 | <.01 | 7.17 | 3.40-15.14 | <.01 |
| Age − (/decade) | 251 | 1.18 | 0.96-1.45 | .11 | 1.20 | 1.05-1.37 | .01 | 1.44 | 1.19-1.74 | <.01 |
| Donor type | ||||||||||
| HLA-matched sibling | 91 | 1.00* | 1.00* | 1.00* | ||||||
| Other related | 18 | 4.77 | 0.58-39.7 | .15 | 1.31 | 0.63-2.72 | .47 | 1.41 | 0.58-3.41 | .45 |
| URD | 124 | 0.58 | 0.30-1.15 | .12 | 1.27 | 0.84-1.91 | .26 | 1.22 | 0.72-2.07 | .46 |
| UCB | 18 | 1.56 | 0.36-6.67 | .55 | 0.72 | 0.32-1.64 | .44 | 1.00 | 0.37-2.71 | .99 |
| Factor . | N . | OR of CR/PR . | 95% CI . | P . | Hazard ratio of 2-y OS . | 95% CI . | P . | Hazard ratio of 2-y NRM . | 95% CI . | P . |
|---|---|---|---|---|---|---|---|---|---|---|
| Minnesota risk/AREG | ||||||||||
| SR, low AREG | 102 | 1.00* | 1.00* | 1.00* | ||||||
| SR, high AREG | 92 | 0.41 | 0.20-0.84 | .02 | 2.30 | 1.48-3.58 | <.01 | 3.62 | 1.93-6.78 | <.01 |
| HR, low AREG | 18 | 0.89 | 0.22-3.61 | .87 | 1.44 | 0.63-3.30 | .39 | 1.14 | 0.23-5.62 | .87 |
| HR, high AREG | 39 | 0.18 | 0.08-0.44 | <.01 | 3.35 | 1.94-5.79 | <.01 | 7.17 | 3.40-15.14 | <.01 |
| Age − (/decade) | 251 | 1.18 | 0.96-1.45 | .11 | 1.20 | 1.05-1.37 | .01 | 1.44 | 1.19-1.74 | <.01 |
| Donor type | ||||||||||
| HLA-matched sibling | 91 | 1.00* | 1.00* | 1.00* | ||||||
| Other related | 18 | 4.77 | 0.58-39.7 | .15 | 1.31 | 0.63-2.72 | .47 | 1.41 | 0.58-3.41 | .45 |
| URD | 124 | 0.58 | 0.30-1.15 | .12 | 1.27 | 0.84-1.91 | .26 | 1.22 | 0.72-2.07 | .46 |
| UCB | 18 | 1.56 | 0.36-6.67 | .55 | 0.72 | 0.32-1.64 | .44 | 1.00 | 0.37-2.71 | .99 |
Bold values are statistically significant.
Reference group.