Lenalidomide trough concentrations in CSF and plasma (16 h after dose)
| Dose, mg/d . | Plasma concentration, ng/mL . | CSF concentration, ng/mL . | Ratio, % . |
|---|---|---|---|
| 10 | 2.07 (2.94); n = 10 | 0.05 (0.16); n = 10 | 2.42 (4.84); n = 4 |
| 15 | 48.7 (45.2); n = 11 | 7.37 (3.04); n = 11 | 20.4 (8.20); n = 11 |
| 20 | 24.8 (59.1); n = 13 | 2.97 (3.03); n = 13 | 25.5 (19.6); n = 8 |
| Dose, mg/d . | Plasma concentration, ng/mL . | CSF concentration, ng/mL . | Ratio, % . |
|---|---|---|---|
| 10 | 2.07 (2.94); n = 10 | 0.05 (0.16); n = 10 | 2.42 (4.84); n = 4 |
| 15 | 48.7 (45.2); n = 11 | 7.37 (3.04); n = 11 | 20.4 (8.20); n = 11 |
| 20 | 24.8 (59.1); n = 13 | 2.97 (3.03); n = 13 | 25.5 (19.6); n = 8 |
Data in the table are shown as mean (standard deviation) with n = number of samples. Concentration below the detection limit is assigned as 0 for plasma and for CSF samples. Ratio is calculated based on the time-matched blood and CSF samples from the same subject.