Associations between demographic and clinical characteristics and joint bleeds in 4771 males with mild or moderate hemophilia
| Characteristic . | No. (%) . | Mean no. of joint bleeds per 6 months . | Invasive procedure, % . |
|---|---|---|---|
| Age group, y | |||
| 2-9 | 1019 (21.4) | 0.38* | 0.3* |
| 10-24 | 1744 (36.6) | 1.20 | 2.9 |
| 25-44 | 911 (19.1) | 2.00 | 11.1 |
| 45+ | 900 (18.9) | 1.09 | 13.9 |
| Race/ethnicity | |||
| White | 3589 (75.2) | 1.10* | 6.6* |
| African American | 362 (7.6) | 2.12 | 8.3 |
| Hispanic | 568 (11.9) | 0.82 | 2.8 |
| Other | 252 (5.3) | 1.39 | 2.0 |
| Insurance | |||
| Commercial | 2853 (59.8) | 1.01* | 5.9 |
| Medicaid/Medicare | 1225 (25.7) | 1.54 | 7.4 |
| Other | 334 (7.0) | 1.00 | 4.2 |
| Uninsured | 334 (7.0) | 1.34 | 5.1 |
| BMI | |||
| Underweight | 21 (0.4) | 1.75 | 14.3* |
| Normal | 2385 (50.0) | 1.13 | 3.4 |
| Overweight | 1145 (24.0) | 1.22 | 9.3 |
| Obese | 1037 (21.7) | 1.06 | 7.3 |
| Hemophilia type | |||
| FVIII deficiency | 3315 (69.5) | 1.28* | 6.5† |
| FIX deficiency | 1456 (30.5) | 0.89 | 5.0 |
| Hemophilia severity | |||
| Moderate | 2049 (43.0) | 2.05* | 8.0* |
| Mild | 2722 (57.0) | 0.49 | 4.6 |
| Baseline FA level, % | |||
| 1-2 | 830 (17.4) | 2.97* | 9.3* |
| 3-5 | 1268 (26.6) | 1.41 | 7.1 |
| 6-9 | 952 (20.0) | 0.68 | 5.2 |
| 10-14 | 733 (15.4) | 0.44 | 4.0 |
| 15-24 | 661 (13.8) | 0.33 | 4.2 |
| 25-40 | 299 (6.3) | 0.33 | 5.0 |
| 41-49 | 28 (0.6) | 0.29 | 3.6 |
| HIV status | |||
| Negative | 4495 (94.2) | 1.03* | 5.4* |
| Positive | 247 (5.2) | 3.63 | 19.0 |
| Hepatitis C status | |||
| Negative | 3309 (69.4) | 0.71* | 3.0* |
| Positive | 1437 (30.1) | 2.22 | 13.2 |
| Hepatitis B status‡ | |||
| Negative | 4707 (98.7) | 1.12* | 5.9* |
| Positive | 64 (1.3) | 4.00 | 20.3 |
| Characteristic . | No. (%) . | Mean no. of joint bleeds per 6 months . | Invasive procedure, % . |
|---|---|---|---|
| Age group, y | |||
| 2-9 | 1019 (21.4) | 0.38* | 0.3* |
| 10-24 | 1744 (36.6) | 1.20 | 2.9 |
| 25-44 | 911 (19.1) | 2.00 | 11.1 |
| 45+ | 900 (18.9) | 1.09 | 13.9 |
| Race/ethnicity | |||
| White | 3589 (75.2) | 1.10* | 6.6* |
| African American | 362 (7.6) | 2.12 | 8.3 |
| Hispanic | 568 (11.9) | 0.82 | 2.8 |
| Other | 252 (5.3) | 1.39 | 2.0 |
| Insurance | |||
| Commercial | 2853 (59.8) | 1.01* | 5.9 |
| Medicaid/Medicare | 1225 (25.7) | 1.54 | 7.4 |
| Other | 334 (7.0) | 1.00 | 4.2 |
| Uninsured | 334 (7.0) | 1.34 | 5.1 |
| BMI | |||
| Underweight | 21 (0.4) | 1.75 | 14.3* |
| Normal | 2385 (50.0) | 1.13 | 3.4 |
| Overweight | 1145 (24.0) | 1.22 | 9.3 |
| Obese | 1037 (21.7) | 1.06 | 7.3 |
| Hemophilia type | |||
| FVIII deficiency | 3315 (69.5) | 1.28* | 6.5† |
| FIX deficiency | 1456 (30.5) | 0.89 | 5.0 |
| Hemophilia severity | |||
| Moderate | 2049 (43.0) | 2.05* | 8.0* |
| Mild | 2722 (57.0) | 0.49 | 4.6 |
| Baseline FA level, % | |||
| 1-2 | 830 (17.4) | 2.97* | 9.3* |
| 3-5 | 1268 (26.6) | 1.41 | 7.1 |
| 6-9 | 952 (20.0) | 0.68 | 5.2 |
| 10-14 | 733 (15.4) | 0.44 | 4.0 |
| 15-24 | 661 (13.8) | 0.33 | 4.2 |
| 25-40 | 299 (6.3) | 0.33 | 5.0 |
| 41-49 | 28 (0.6) | 0.29 | 3.6 |
| HIV status | |||
| Negative | 4495 (94.2) | 1.03* | 5.4* |
| Positive | 247 (5.2) | 3.63 | 19.0 |
| Hepatitis C status | |||
| Negative | 3309 (69.4) | 0.71* | 3.0* |
| Positive | 1437 (30.1) | 2.22 | 13.2 |
| Hepatitis B status‡ | |||
| Negative | 4707 (98.7) | 1.12* | 5.9* |
| Positive | 64 (1.3) | 4.00 | 20.3 |