Multivariable analysis of associations between demographic and clinical characteristics and having an invasive orthopedic procedure in 4771 males with mild or moderate hemophilia
| Characteristic . | OR . | 95% CI . | P . |
|---|---|---|---|
| Age group, y | |||
| 2-9 | Ref | ||
| 10-24 | 2.1 | 1.1-4.0 | .02 |
| 25-44 | 5.7 | 3.0-10.9 | < .001 |
| 45+ | 7.7 | 4.1-14.7 | < .001 |
| Race/ethnicity | |||
| White | Ref | ||
| African American | 1.1 | 0.7-1.8 | .7 |
| Hispanic | 0.5 | 0.3-0.9 | .03 |
| Other | 0.5 | 0.2-1.2 | .1 |
| Insurance | |||
| Commercial | Ref | ||
| Medicaid/Medicare | 1.2 | 0.9-1.6 | .3 |
| Other | 0.7 | 0.4-1.3 | .3 |
| Uninsured | 0.7 | 0.4-1.2 | .2 |
| BMI | |||
| Normal | Ref | ||
| Underweight | 1.3 | 0.4-5.0 | .7 |
| Overweight | 1.6 | 1.2-2.2 | .004 |
| Obese | 1.5 | 1.1-2.2 | .01 |
| Hemophilia type | |||
| FVIII | Ref | ||
| FIX | 0.7 | 0.5-0.9 | .04 |
| HIV infection | |||
| Negative | Ref | ||
| Positive | 1.6 | 1.1-2.4 | .03 |
| Hepatitis C infection | |||
| Negative | Ref | ||
| Positive | 1.7 | 1.2-2.3 | .004 |
| Hepatitis B infection | |||
| Negative | Ref | ||
| Positive | 1.4 | 0.7-2.8 | .4 |
| Baseline FA level | 0.96 | 0.95-0.98 | < .001 |
| Characteristic . | OR . | 95% CI . | P . |
|---|---|---|---|
| Age group, y | |||
| 2-9 | Ref | ||
| 10-24 | 2.1 | 1.1-4.0 | .02 |
| 25-44 | 5.7 | 3.0-10.9 | < .001 |
| 45+ | 7.7 | 4.1-14.7 | < .001 |
| Race/ethnicity | |||
| White | Ref | ||
| African American | 1.1 | 0.7-1.8 | .7 |
| Hispanic | 0.5 | 0.3-0.9 | .03 |
| Other | 0.5 | 0.2-1.2 | .1 |
| Insurance | |||
| Commercial | Ref | ||
| Medicaid/Medicare | 1.2 | 0.9-1.6 | .3 |
| Other | 0.7 | 0.4-1.3 | .3 |
| Uninsured | 0.7 | 0.4-1.2 | .2 |
| BMI | |||
| Normal | Ref | ||
| Underweight | 1.3 | 0.4-5.0 | .7 |
| Overweight | 1.6 | 1.2-2.2 | .004 |
| Obese | 1.5 | 1.1-2.2 | .01 |
| Hemophilia type | |||
| FVIII | Ref | ||
| FIX | 0.7 | 0.5-0.9 | .04 |
| HIV infection | |||
| Negative | Ref | ||
| Positive | 1.6 | 1.1-2.4 | .03 |
| Hepatitis C infection | |||
| Negative | Ref | ||
| Positive | 1.7 | 1.2-2.3 | .004 |
| Hepatitis B infection | |||
| Negative | Ref | ||
| Positive | 1.4 | 0.7-2.8 | .4 |
| Baseline FA level | 0.96 | 0.95-0.98 | < .001 |
The regression model included at a minimum the covariates of age group, race/ethnicity, insurance type, BMI category, hemophilia type, hepatitis B and C, HIV status, and baseline FA level. Invasive orthopedic procedures included arthrodesis; joint replacement; arthroscopic, radioisotopic, or open synovectomy; and any other invasive procedure.