Comparison between the ARIC, NHANES, and hemophilia cohorts
| Variable . | Hemophilia, % . | ARIC, % . | ARIC vs hemophilia, P . | NHANES, % . | NHANES vs hemophilia, P . |
|---|---|---|---|---|---|
| CVD (ARIC definition)* | 15.0 | 25.8 | <.001 | ||
| CVD (NHANES definition)* | 10.0 | 17.9 | .003 | ||
| ASA use in patients with CVD | 10.0 | 59.0 | <.001 | 22.7 | .024 |
| Age ≥ 65 y | 25.0 | 43.5 | <.001 | 37.2 | <.001 |
| White | 88.5 | 82.4 | .013 | ||
| Hypertension | 64.5 | 46.3 | <.001 | 55.0 | .007 |
| Antihypertensive medication (in patients with hypertension) | 55.8 | 76.4 | <.001 | 85.0 | <.001 |
| Dyslipidemia | 63.5 | 63.7 | .477 | 56.8† | .042 |
| Use of lipid-lower medication (in patients with dyslipidemia) | 27.6 | 25.6 | .307 | 67.3† | <.001 |
| Diabetes mellitus | 21.0 | 18.4 | .177 | 28.0 | .022 |
| Diabetes medication (in patients with diabetes) | 45.2 | 55.7 | .091 | 75.9 | <.001 |
| Ever smoker | 48.5 | 72.7 | <.001 | 61.6 | <.001 |
| Family history of CVD | 43.5 | 22.0 | <.001 | ||
| Obesity | 29.5 | 31.5 | .275 | 34.7 | .081 |
| Increased waist circumference | 30.0 | 48.8 | <.001 | 50.5 | <.001 |
| Elevated creatinine | 26.8 | 7.4 | <.001 | ||
| Elevated CRP | 9.8 | 5.0 | .002 |
| Variable . | Hemophilia, % . | ARIC, % . | ARIC vs hemophilia, P . | NHANES, % . | NHANES vs hemophilia, P . |
|---|---|---|---|---|---|
| CVD (ARIC definition)* | 15.0 | 25.8 | <.001 | ||
| CVD (NHANES definition)* | 10.0 | 17.9 | .003 | ||
| ASA use in patients with CVD | 10.0 | 59.0 | <.001 | 22.7 | .024 |
| Age ≥ 65 y | 25.0 | 43.5 | <.001 | 37.2 | <.001 |
| White | 88.5 | 82.4 | .013 | ||
| Hypertension | 64.5 | 46.3 | <.001 | 55.0 | .007 |
| Antihypertensive medication (in patients with hypertension) | 55.8 | 76.4 | <.001 | 85.0 | <.001 |
| Dyslipidemia | 63.5 | 63.7 | .477 | 56.8† | .042 |
| Use of lipid-lower medication (in patients with dyslipidemia) | 27.6 | 25.6 | .307 | 67.3† | <.001 |
| Diabetes mellitus | 21.0 | 18.4 | .177 | 28.0 | .022 |
| Diabetes medication (in patients with diabetes) | 45.2 | 55.7 | .091 | 75.9 | <.001 |
| Ever smoker | 48.5 | 72.7 | <.001 | 61.6 | <.001 |
| Family history of CVD | 43.5 | 22.0 | <.001 | ||
| Obesity | 29.5 | 31.5 | .275 | 34.7 | .081 |
| Increased waist circumference | 30.0 | 48.8 | <.001 | 50.5 | <.001 |
| Elevated creatinine | 26.8 | 7.4 | <.001 | ||
| Elevated CRP | 9.8 | 5.0 | .002 |