Table 1. How we manage pregnancy in... | American Society of Hematology

Table 1.

How we manage pregnancy in myeloproliferative disease (MPD).

* Severe pregnancy complications: ≥ 3 first-trimester or ≥ 1 second or third-trimester losses, birth weight < 5th centile of gestation, pre-eclampsia, intrauterine death or stillbirth.
Risk stratification At least one of the following defines high-risk pregnancy: - previous major thrombotic or bleeding complication - previous severe pregnancy complications* - platelet count > 1500 × 10⁹/L Therapy Low-risk pregnancy - Target hematocrit should be kept below 45% - Aspirin 100 mg/day - Low-molecular-weight heparin (LMWH) 4000 U/day after delivery until 6 weeks postpartum High-risk pregnancy As above, plus - If previous major thrombosis or severe pregnancy complications: LMWH throughout pregnancy (stop aspirin if bleeding complications) - If platelet count > 1500 × 10⁹/L: consider interferon (IFN)-α - If previous major bleeding: avoid aspirin and consider IFN-α to reduce thrombocytosis