Risk group assignments of younger adults with acute myeloid leukemia (AML) with the more frequent cytogenetic findings.
| Bold type denotes chromosome aberrations whose prognostic impact is agreed on by major studies.1 –3 | |
| * No clonal abnormality detected in 20 or more fully analyzed marrow metaphase cells. | |
| † Would be included in “abn 11q” group and classified in the adverse-risk category by Slovak et al.2 | |
| ‡ Classified in the adverse-risk category by Slovak et al.2 | |
| § Would be included in “abn 20q” group and classified in the adverse-risk category by Slovak et al.2 | |
| || Classified in the adverse-risk category with respect to overall survival by Byrd et al.3 | |
| ¶ Defined as the presence of 3 or more abnormalities in karyotypes not including inv(16), t(16;16), t(8;21), t(15;17) or t(9;11). | |
| # Classified in the intermediate-risk category by virtue of being “other structural” abnormality by Grimwade et al.1 In a study of Byrd et al.3 included in the intermediate-risk category only with respect to probability of achievement of CR. | |
| ** Would be included in “abnormal 11q23” group and classified in the intermediate-risk category by Grimwade et al.1 In a study of Byrd et al.3 included in the intermediate-risk category only with regard to probability of achievement of CR. | |
| †† Classified in the intermediate-risk category with respect to probability of achievement of CR and survival by Byrd et al.3 but only if not part of a complex karyotype. | |
| Favorable-Risk Group | |
| Balanced structural rearrangements: | t(15;17)(q22;q12–21) t(8;21)(q22;q22) inv(16)(p13q22)/t(16;16)(p13;q22) |
| Intermediate-Risk Group | |
| Normal karyotype* | |
| Balanced structural rearrangement: | t(9;11)(p22;q23)† |
| Unbalanced structural rearrangements: | del(7q)‡ del(9q)‡ del(11q)† del(20q)§ |
| Numerical aberrations: | −Y +8|| +11 +13 +21 |
| Unfavorable-Risk Group | |
| Complex karyotype¶ | |
| Balanced structural rearrangements: | inv(3)(q21q26)/t(3;3)(q21;q26) t(6;9)(p23;q34) # t(6;11)(q27;q23)** t(11;19)(q23;p13.1)** |
| Unbalanced structural rearrangement: | del(5q)†† |
| Numerical aberrations: | −5 −7 |
| Bold type denotes chromosome aberrations whose prognostic impact is agreed on by major studies.1 –3 | |
| * No clonal abnormality detected in 20 or more fully analyzed marrow metaphase cells. | |
| † Would be included in “abn 11q” group and classified in the adverse-risk category by Slovak et al.2 | |
| ‡ Classified in the adverse-risk category by Slovak et al.2 | |
| § Would be included in “abn 20q” group and classified in the adverse-risk category by Slovak et al.2 | |
| || Classified in the adverse-risk category with respect to overall survival by Byrd et al.3 | |
| ¶ Defined as the presence of 3 or more abnormalities in karyotypes not including inv(16), t(16;16), t(8;21), t(15;17) or t(9;11). | |
| # Classified in the intermediate-risk category by virtue of being “other structural” abnormality by Grimwade et al.1 In a study of Byrd et al.3 included in the intermediate-risk category only with respect to probability of achievement of CR. | |
| ** Would be included in “abnormal 11q23” group and classified in the intermediate-risk category by Grimwade et al.1 In a study of Byrd et al.3 included in the intermediate-risk category only with regard to probability of achievement of CR. | |
| †† Classified in the intermediate-risk category with respect to probability of achievement of CR and survival by Byrd et al.3 but only if not part of a complex karyotype. | |
| Favorable-Risk Group | |
| Balanced structural rearrangements: | t(15;17)(q22;q12–21) t(8;21)(q22;q22) inv(16)(p13q22)/t(16;16)(p13;q22) |
| Intermediate-Risk Group | |
| Normal karyotype* | |
| Balanced structural rearrangement: | t(9;11)(p22;q23)† |
| Unbalanced structural rearrangements: | del(7q)‡ del(9q)‡ del(11q)† del(20q)§ |
| Numerical aberrations: | −Y +8|| +11 +13 +21 |
| Unfavorable-Risk Group | |
| Complex karyotype¶ | |
| Balanced structural rearrangements: | inv(3)(q21q26)/t(3;3)(q21;q26) t(6;9)(p23;q34) # t(6;11)(q27;q23)** t(11;19)(q23;p13.1)** |
| Unbalanced structural rearrangement: | del(5q)†† |
| Numerical aberrations: | −5 −7 |