EORTC guidelines for mycosis fungoides/Sézary syndrome (MF/SS) treatment.3
| . | First Line . | Second Line . |
|---|---|---|
| Abbreviations: PUVA, photochemotherapy; IFN, interferon; UVB, ultra-violet B; EBRT, external beam radiation therapy; BCNU, carmustine | ||
| MF Stage IA, IB, IIA | PUVA UVB (patches only) Topical Corticosteroids Localized Radiotherapy EBRT Topical Nitrogen Mustard Topical BCNU | Oral Bexarotene ± PUVA or IFN-α IFN-α ± PUVA Denileukin difitox Low-dose Methotrexate |
| MF Stage IIB | IFN-α + PUVA IFN-α + Retinoids PUVA + Retinoids EBRT and superficial x-irradiation | Bexarotene Chemotherapy Denileukin difitox |
| MF Stage III | IFN-α PUVA + IFN-α or Retinoids Methotrexate EBRT/x-irradiation Topical Nitrogen Mustard or BCNU Extracoporeal photophoresis | Chemotherapy |
| MF Stage IVA and IVB | Chemotherapy EBRT and/or x-irradiation Bexarotene Denileukin difitox IFN-α Alemtuzumab Methotrexate | |
| Sézary syndrome | Extracoporeal photophoresis IFN-α Denileukin difitox Chlorambucil and prednisone | Bexarotene Chemotherapy Alemtuzumab Methotrexate |
| . | First Line . | Second Line . |
|---|---|---|
| Abbreviations: PUVA, photochemotherapy; IFN, interferon; UVB, ultra-violet B; EBRT, external beam radiation therapy; BCNU, carmustine | ||
| MF Stage IA, IB, IIA | PUVA UVB (patches only) Topical Corticosteroids Localized Radiotherapy EBRT Topical Nitrogen Mustard Topical BCNU | Oral Bexarotene ± PUVA or IFN-α IFN-α ± PUVA Denileukin difitox Low-dose Methotrexate |
| MF Stage IIB | IFN-α + PUVA IFN-α + Retinoids PUVA + Retinoids EBRT and superficial x-irradiation | Bexarotene Chemotherapy Denileukin difitox |
| MF Stage III | IFN-α PUVA + IFN-α or Retinoids Methotrexate EBRT/x-irradiation Topical Nitrogen Mustard or BCNU Extracoporeal photophoresis | Chemotherapy |
| MF Stage IVA and IVB | Chemotherapy EBRT and/or x-irradiation Bexarotene Denileukin difitox IFN-α Alemtuzumab Methotrexate | |
| Sézary syndrome | Extracoporeal photophoresis IFN-α Denileukin difitox Chlorambucil and prednisone | Bexarotene Chemotherapy Alemtuzumab Methotrexate |