Table 2. In vivo birth rates of B-CLL... | American Society of Hematology

Table 2.

In vivo birth rates of B-CLL cells correlate with disease progression.

Patient No.	Birth Rate (%/day)	Active/Progressive Disease¹	Treatment²	Mutation Status (% difference)³
1. Based on National Cancer Institute criteria ( BD Cheson et al. Blood 1996 ; 87 : 4990 –4997 )
2. Timed in relation to the heavy water protocol
3. Percent difference in nucleotide sequence between the expressed IgVH gene of the B-CLL patient and the most similar germline counterpart.
4. This leukemic clone expressed two VHDJH rearrangements.
400	1.76	Yes	Pre and Post	0.0
408	1.09	No	No	0.3
189	0.81	Yes	Pre and Post	0.3, 6.8⁴
472	0.54	Yes	No	0.0
169	0.49	Yes	Post	5.1
360	0.48	No	No	0.3
355	0.45	Yes	Post	0.0
336	0.41	Yes	Post	2.0
403	0.39	Yes	Post	0.0
282	0.39	Yes	Pre and Post	2.4
321	0.29	No	No	0.3
418	0.28	No	No	4.0
331	0.24	No	No	3.7
332	0.24	Yes	Post	1.0
107	0.23	No	No	6.9
280	0.22	No	No	—
394	0.18	No	No	0.0
109	0.11	No	No	7.1

Patient No.	Birth Rate (%/day)	Active/Progressive Disease¹	Treatment²	Mutation Status (% difference)³
1. Based on National Cancer Institute criteria ( BD Cheson et al. Blood 1996 ; 87 : 4990 –4997 )
2. Timed in relation to the heavy water protocol
3. Percent difference in nucleotide sequence between the expressed IgVH gene of the B-CLL patient and the most similar germline counterpart.
4. This leukemic clone expressed two VHDJH rearrangements.
400	1.76	Yes	Pre and Post	0.0
408	1.09	No	No	0.3
189	0.81	Yes	Pre and Post	0.3, 6.8⁴
472	0.54	Yes	No	0.0
169	0.49	Yes	Post	5.1
360	0.48	No	No	0.3
355	0.45	Yes	Post	0.0
336	0.41	Yes	Post	2.0
403	0.39	Yes	Post	0.0
282	0.39	Yes	Pre and Post	2.4
321	0.29	No	No	0.3
418	0.28	No	No	4.0
331	0.24	No	No	3.7
332	0.24	Yes	Post	1.0
107	0.23	No	No	6.9
280	0.22	No	No	—
394	0.18	No	No	0.0
109	0.11	No	No	7.1