Frequency and median survival of cytogenetic prognostic subgroups
| Anomaly . | Frequency, % . | Median survival, mo . |
|---|---|---|
| Good-prognosis cytogenetics | ||
| del(9q), NC | 0.4 | NR |
| del(15q), NC | 0.4 | NR |
| t(15q), NC | 0.4 | NR |
| del(12p), NC | 0.8 | 108.0 |
| +21, NC | 1.1 | 100.8 |
| −Y, +1 | 0.4 | 84.6 |
| del(5q), isolated | 8.2 | 80.0 |
| +21, +1 | 0.8 | 80.0 |
| del(5q), NC | 10.7 | 77.2 |
| del(20q), isolated | 1.9 | 71.0 |
| del(20q), NC | 2.2 | 71.0 |
| −X, NC | 0.5 | 56.4 |
| No (normal karyotype) | 49.5 | 53.4 |
| del(5q), +1 | 2.5 | 47.0 |
| +8, +1 | 1.2 | 44.0 |
| −Y, NC | 2.7 | 39.0 |
| −Y, sole | 3.5 | 36.0 |
| +1/+1q, NC | 0.4 | 34.7 |
| t(1q), NC | 0.6 | 34.7 |
| t(7q), NC | 0.6 | 34.7 |
| t(11q), NC | 0.5 | 32.1 |
| −21, NC | 0.5 | 32.0 |
| Intermediate-prognosis cytogenetics | ||
| del(11q), NC | 0.9 | 26.1 |
| +8, NC | 5.0 | 23.0 |
| +8, isolated | 3.8 | 22.0 |
| t(11q23), NC | 0.5 | 20.0 |
| Rea 3q, NC | 0.5 | 19.9 |
| +19, NC | 0.4 | 19.8 |
| del(7q), isolated and NC | 0.6 | 19.0 |
| Any 3 abnormalities | 2.8 | 17.1 |
| del(11q), isolated | 0.6 | 15.9 |
| −7, +1 | 0.9 | 14.4 |
| −5, NC | 0.4 | 14.6 |
| −7, sole | 2.3 | 14.0 |
| −7, NC | 3.2 | 14.0 |
| Poor-prognosis cytogenetics | ||
| Complex, all | 13.4 | 8.7 |
| t(5q), NC | 0.4 | 4.4 |
| Four to 6 abnormalities | 5.3 | 9.0 |
| More than 6 abnormalities | 3.9 | 5.0 |
| Anomaly . | Frequency, % . | Median survival, mo . |
|---|---|---|
| Good-prognosis cytogenetics | ||
| del(9q), NC | 0.4 | NR |
| del(15q), NC | 0.4 | NR |
| t(15q), NC | 0.4 | NR |
| del(12p), NC | 0.8 | 108.0 |
| +21, NC | 1.1 | 100.8 |
| −Y, +1 | 0.4 | 84.6 |
| del(5q), isolated | 8.2 | 80.0 |
| +21, +1 | 0.8 | 80.0 |
| del(5q), NC | 10.7 | 77.2 |
| del(20q), isolated | 1.9 | 71.0 |
| del(20q), NC | 2.2 | 71.0 |
| −X, NC | 0.5 | 56.4 |
| No (normal karyotype) | 49.5 | 53.4 |
| del(5q), +1 | 2.5 | 47.0 |
| +8, +1 | 1.2 | 44.0 |
| −Y, NC | 2.7 | 39.0 |
| −Y, sole | 3.5 | 36.0 |
| +1/+1q, NC | 0.4 | 34.7 |
| t(1q), NC | 0.6 | 34.7 |
| t(7q), NC | 0.6 | 34.7 |
| t(11q), NC | 0.5 | 32.1 |
| −21, NC | 0.5 | 32.0 |
| Intermediate-prognosis cytogenetics | ||
| del(11q), NC | 0.9 | 26.1 |
| +8, NC | 5.0 | 23.0 |
| +8, isolated | 3.8 | 22.0 |
| t(11q23), NC | 0.5 | 20.0 |
| Rea 3q, NC | 0.5 | 19.9 |
| +19, NC | 0.4 | 19.8 |
| del(7q), isolated and NC | 0.6 | 19.0 |
| Any 3 abnormalities | 2.8 | 17.1 |
| del(11q), isolated | 0.6 | 15.9 |
| −7, +1 | 0.9 | 14.4 |
| −5, NC | 0.4 | 14.6 |
| −7, sole | 2.3 | 14.0 |
| −7, NC | 3.2 | 14.0 |
| Poor-prognosis cytogenetics | ||
| Complex, all | 13.4 | 8.7 |
| t(5q), NC | 0.4 | 4.4 |
| Four to 6 abnormalities | 5.3 | 9.0 |
| More than 6 abnormalities | 3.9 | 5.0 |
NC indicates noncomplex karyotype; and NR, not reached.