Single locus mismatches at HLA-A, -B, -C, and -DRB1
| Factor . | Survival . | Disease-free survival . | Treatment-related mortality . | Acute graft-versus-host disease . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | |
| Any single locus (n = 985) vs matched (n=1840) | 1.25 | 1.13-1.38 | <.001 | 1.23 | 1.12-1.36 | <.001 | 1.40 | 1.25-1.56 | <.001 | 1.48 | 1.29-1.68 | <.001 |
| Any single allele (n=412) vs matched | 1.30 | 1.14-1.46 | <.001 | 1.28 | 1.13-1.46 | .002 | 1.40 | 1.20-1.63 | <.001 | 1.34 | 1.12-1.61 | .002 |
| Any single antigen (n=573) vs matched | 1.22 | 1.08-1.37 | .001 | 1.20 | 1.07-1.35 | .002 | 1.40 | 1.22-1.60 | <.001 | 1.59 | 1.35-1.86 | <.001 |
| Any single allele vs any single antigen | 1.07 | 0.92-1.24 | .40 | 1.07 | 0.92-1.24 | .39 | 1.00 | 0.83-1.19 | .98 | 0.85 | 0.68-1.04 | .12 |
| Factor . | Survival . | Disease-free survival . | Treatment-related mortality . | Acute graft-versus-host disease . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | |
| Any single locus (n = 985) vs matched (n=1840) | 1.25 | 1.13-1.38 | <.001 | 1.23 | 1.12-1.36 | <.001 | 1.40 | 1.25-1.56 | <.001 | 1.48 | 1.29-1.68 | <.001 |
| Any single allele (n=412) vs matched | 1.30 | 1.14-1.46 | <.001 | 1.28 | 1.13-1.46 | .002 | 1.40 | 1.20-1.63 | <.001 | 1.34 | 1.12-1.61 | .002 |
| Any single antigen (n=573) vs matched | 1.22 | 1.08-1.37 | .001 | 1.20 | 1.07-1.35 | .002 | 1.40 | 1.22-1.60 | <.001 | 1.59 | 1.35-1.86 | <.001 |
| Any single allele vs any single antigen | 1.07 | 0.92-1.24 | .40 | 1.07 | 0.92-1.24 | .39 | 1.00 | 0.83-1.19 | .98 | 0.85 | 0.68-1.04 | .12 |
Numbers in each group are for the survival model. Other models may have had fewer evaluable patients, as described in “Biostatistical methods.”
RR indicates relative risk; and CI, confidence interval.