Association between patient and donor characteristics and survival
| Variable/category . | No. . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|---|
| HLA match | ||||
| 8/8 | 1840 | 1.00 | — | — |
| 7/8 | 985 | 1.25 | 1.13-1.37 | <.001 |
| 6/8 | 633 | 1.65 | 1.48-1.84 | <.001 |
| Disease diagnosis | ||||
| AML | 969 | 1.00 | — | — |
| ALL | 834 | 1.07 | 0.95-1.20 | .25 |
| CML | 1367 | 0.78 | 0.69-0.87 | <.001 |
| MDS | 288 | 0.73 | 0.62-0.86 | <.001 |
| Disease status | ||||
| Early | 1454 | 1.00 | — | — |
| Intermediate | 1352 | 1.38 | 1.25-1.53 | <.001 |
| Late | 645 | 1.90 | 1.67-2.16 | <.001 |
| Patient age, y | ||||
| Younger than 31 | 1467 | 1.00 | — | — |
| 31 to 45 | 1263 | 1.51 | 1.36-1.67 | <.001 |
| Older than 45 | 728 | 1.79 | 1.59-2.02 | <.001 |
| Patient race | ||||
| White | 3077 | 1.00 | — | — |
| Black | 132 | 1.53 | 1.26-1.87 | <.001 |
| Hispanic | 170 | 1.05 | 0.87-1.27 | .62 |
| Other | 78 | 0.68 | 0.51-0.92 | .012 |
| Donor/recipient, CMV | ||||
| −/− | 1209 | 1.00 | — | — |
| −/+ | 969 | 1.31 | 1.18-1.45 | <.001 |
| +/− | 555 | 1.08 | 0.95-1.23 | .23 |
| +/+ | 623 | 1.36 | 1.20-1.54 | <.001 |
| Unknown | 102 | 1.34 | 1.06-1.71 | .016 |
| Donor/recipient, sex match | ||||
| M/M | 1246 | 1.00 | — | — |
| M/F | 824 | 1.00 | 0.90-1.11 | .99 |
| F/M | 693 | 0.99 | 0.86-1.15 | .89 |
| F/F | 695 | 1.03 | 0.90-1.19 | .65 |
| Donor parity | ||||
| Male or not parous | 2615 | 1.00 | — | — |
| Parous | 814 | 1.10 | 0.96-1.27 | .17 |
| Donor age, y | ||||
| Younger than 31 | 887 | 1.00 | — | — |
| 31 to 45 | 1929 | 1.05 | 0.95-1.16 | .38 |
| Older than 45 | 642 | 1.06 | 0.93-1.20 | .42 |
| Variable/category . | No. . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|---|
| HLA match | ||||
| 8/8 | 1840 | 1.00 | — | — |
| 7/8 | 985 | 1.25 | 1.13-1.37 | <.001 |
| 6/8 | 633 | 1.65 | 1.48-1.84 | <.001 |
| Disease diagnosis | ||||
| AML | 969 | 1.00 | — | — |
| ALL | 834 | 1.07 | 0.95-1.20 | .25 |
| CML | 1367 | 0.78 | 0.69-0.87 | <.001 |
| MDS | 288 | 0.73 | 0.62-0.86 | <.001 |
| Disease status | ||||
| Early | 1454 | 1.00 | — | — |
| Intermediate | 1352 | 1.38 | 1.25-1.53 | <.001 |
| Late | 645 | 1.90 | 1.67-2.16 | <.001 |
| Patient age, y | ||||
| Younger than 31 | 1467 | 1.00 | — | — |
| 31 to 45 | 1263 | 1.51 | 1.36-1.67 | <.001 |
| Older than 45 | 728 | 1.79 | 1.59-2.02 | <.001 |
| Patient race | ||||
| White | 3077 | 1.00 | — | — |
| Black | 132 | 1.53 | 1.26-1.87 | <.001 |
| Hispanic | 170 | 1.05 | 0.87-1.27 | .62 |
| Other | 78 | 0.68 | 0.51-0.92 | .012 |
| Donor/recipient, CMV | ||||
| −/− | 1209 | 1.00 | — | — |
| −/+ | 969 | 1.31 | 1.18-1.45 | <.001 |
| +/− | 555 | 1.08 | 0.95-1.23 | .23 |
| +/+ | 623 | 1.36 | 1.20-1.54 | <.001 |
| Unknown | 102 | 1.34 | 1.06-1.71 | .016 |
| Donor/recipient, sex match | ||||
| M/M | 1246 | 1.00 | — | — |
| M/F | 824 | 1.00 | 0.90-1.11 | .99 |
| F/M | 693 | 0.99 | 0.86-1.15 | .89 |
| F/F | 695 | 1.03 | 0.90-1.19 | .65 |
| Donor parity | ||||
| Male or not parous | 2615 | 1.00 | — | — |
| Parous | 814 | 1.10 | 0.96-1.27 | .17 |
| Donor age, y | ||||
| Younger than 31 | 887 | 1.00 | — | — |
| 31 to 45 | 1929 | 1.05 | 0.95-1.16 | .38 |
| Older than 45 | 642 | 1.06 | 0.93-1.20 | .42 |
M indicates male; F, female; and —, not applicable.