Table 1 Mutations of TP53 in DLBCL Case... | American Society of Hematology

Table 1

Mutations of TP53 in DLBCL

Case	Group	Exon	Codon	TP53 domain	Nucleotide change	Amino acid change	Follow-up, status (mo)
1	GCB	5	132	S2	AAG>AAT	Lys>Asn	Dead (132)
2	ABC	5	152	S3	CCG>C-G	Pro>Arg*	Alive (101)
3	GCB	5	158	S4	CGC>CAC	Arg>His	Dead (18)
4	ABC	5	173	L2	GTG>GCG	Val>Ala	Alive (92)
5	ABC	5	175	L2	CGC>CAC	Arg>His	Dead (5)
6	ABC	5	176	L2	TGC>CGC	Cys>Arg	Dead (4)
7	GCB	6	211	S6	ACT>ATT	Thr>Ile	Alive (97)
8	ABC	6	213	S6	CGA>TGA	Arg>Stop	Dead (7)
9	ABC	6	213	S6	CGA>TGA	Arg>Stop	Alive (137)
10	GCB	6	215	S7	AGT>AGG	Ser>Arg	Dead (5)
11	GCB	6	216	S7	GTG>ATG	Val>Met	Dead (8)
12	ABC	7	229	S8	TGT>TGA	Cys>Stop	Dead (20)
12^Δ	—	7	254	S9	ATC>AGC	Ile>Ser	—
13	ABC	7	234	S8	TAC>AAC	Tyr>Asn	Dead (30)
14	GCB	7	248	L3	CGG>CAG	Arg>Gln	Dead (5)
15	ABC	7	248	L3	CGG>CAG	Arg>Gln	Dead (6)
16	Unclass	7	248	L3	CGG>CAG	Arg>Gln	Alive (62)
17	Unclass	7	248	L3	CGG>TGG	Arg>Trp	Dead (11)
18	GCB	7	251	L3	ATC>TTC	Ile>Phe	Dead (10)
19	GCB	8	272	S10	GTG>GAG	Val>Glu	N/A
20	GCB	8	273	S10	CGT>CCT	Arg>Pro	Dead (8)
21	GCB	8	273	S10	CGT>TGT	Arg>Cys	Dead (36)
22	GCB	8	280	H2	AGA>AGT	Arg>Ser	Dead (8)
23	ABC	8	280	H2	AGA>ATA	Arg>Ile	Dead (12)
24	ABC	8	283	H2	CGC>(I)CGC	Arg>Leu†	Alive (49)

Case	Group	Exon	Codon	TP53 domain	Nucleotide change	Amino acid change	Follow-up, status (mo)
1	GCB	5	132	S2	AAG>AAT	Lys>Asn	Dead (132)
2	ABC	5	152	S3	CCG>C-G	Pro>Arg*	Alive (101)
3	GCB	5	158	S4	CGC>CAC	Arg>His	Dead (18)
4	ABC	5	173	L2	GTG>GCG	Val>Ala	Alive (92)
5	ABC	5	175	L2	CGC>CAC	Arg>His	Dead (5)
6	ABC	5	176	L2	TGC>CGC	Cys>Arg	Dead (4)
7	GCB	6	211	S6	ACT>ATT	Thr>Ile	Alive (97)
8	ABC	6	213	S6	CGA>TGA	Arg>Stop	Dead (7)
9	ABC	6	213	S6	CGA>TGA	Arg>Stop	Alive (137)
10	GCB	6	215	S7	AGT>AGG	Ser>Arg	Dead (5)
11	GCB	6	216	S7	GTG>ATG	Val>Met	Dead (8)
12	ABC	7	229	S8	TGT>TGA	Cys>Stop	Dead (20)
12^Δ	—	7	254	S9	ATC>AGC	Ile>Ser	—
13	ABC	7	234	S8	TAC>AAC	Tyr>Asn	Dead (30)
14	GCB	7	248	L3	CGG>CAG	Arg>Gln	Dead (5)
15	ABC	7	248	L3	CGG>CAG	Arg>Gln	Dead (6)
16	Unclass	7	248	L3	CGG>CAG	Arg>Gln	Alive (62)
17	Unclass	7	248	L3	CGG>TGG	Arg>Trp	Dead (11)
18	GCB	7	251	L3	ATC>TTC	Ile>Phe	Dead (10)
19	GCB	8	272	S10	GTG>GAG	Val>Glu	N/A
20	GCB	8	273	S10	CGT>CCT	Arg>Pro	Dead (8)
21	GCB	8	273	S10	CGT>TGT	Arg>Cys	Dead (36)
22	GCB	8	280	H2	AGA>AGT	Arg>Ser	Dead (8)
23	ABC	8	280	H2	AGA>ATA	Arg>Ile	Dead (12)
24	ABC	8	283	H2	CGC>(I)CGC	Arg>Leu†	Alive (49)

Δ case 12 has two TP53 mutations.

Unclass indicates unclassified; N/A, not applicable; I, CTTAACCCGG; and —, same as line above.

Stop at 169.

Stop at 308.