Table 3

Differential mRNA expression in DLBCL with TP53 mutations

Gene symbolLocationGene descriptionFold difference
TNFRSF10B (DR5) 8p22-p21 Tumor necrosis factor receptor superfamily, member 10b (TRAIL receptor 2) −1.45* 
LCP2 (SLP-76) 5q33.1-qter Tyrosine phosphoprotein SLP-76 −1.91* 
ARL7 2q37.1 ADP-ribosylation factor-like 7 −1.83* 
AIF-1 6p21.3 Allograft-inflammatory factor-1 −1.74 
XPC 3p25 Xeroderma pigmentosum, complementation group C −1.46* 
CD11A 16p11.2 CD11A, Integrin, alpha L; LFA-1 alpha chain −1.46 
DDB2 11p12-p11 Damage-specific DNA binding protein 2 −1.56* 
TP53 17p13.1 p53 Tumor suppressor −1.58 
CABIN1 22q11.23 Negative regulator for calcineurin signaling in T lymphocytes −1.31 
TXNIP 1q21.1 Thioredoxin-interacting protein −1.88 
LILRB1 19q13.4 Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 −1.73 
ARHGEF1 19q13.13 Rho guanine nucleotide exchange factor (GEF) 1 −1.37 
ARRB2 17p13 Arrestin beta 2 −1.42* 
FYN 6q21 Tyrosine protein kinase −1.92* 
FYB 5p13.1 SLAP-130, SLP-76 associated protein; FYN, binding protein −1.85 
DPH2L 17p13.3 Similar to diphthamide biosynthesis gene DPH2 of Saccharomyces cerevisiae −1.33 
CDKN1A (p21) 6p21.2 Cyclin kinase inhibitor, WAF1, CIP1 −1.56 
FCGRT 19q13.3 IgG Fc receptor hFcRn −1.73 
NSF 17q21 Ribosomal protein S7 −1.69 
TCRA 14q11.2 T-cell receptor alpha chain −1.99 
CD64 1q21.1 High-affinity immunoglobulin gamma FC receptor I A −3.36 
PSRY5 13q14 Purinergic receptor P2Y5 −2.30 
LSP1 11p15.5 Lymphocyte-specific protein −1.75* 
BTG1 12q22 B-cell translocation gene 1 −1.61 
TOP3A 17p12-p11.2 Topoisomerase DNA III alpha −1.36 
BAX 19q13.3-4 BCL2-associated X protein −1.52 
GBP2 1p22.2 Guanylate-binding protein 2, interferon-inducible −1.93 
NK4 16p13.3 Interleukin 32 −2.08 
SPAG7 17p13.2 Sperm-associated antigen −1.35 
Gene symbolLocationGene descriptionFold difference
TNFRSF10B (DR5) 8p22-p21 Tumor necrosis factor receptor superfamily, member 10b (TRAIL receptor 2) −1.45* 
LCP2 (SLP-76) 5q33.1-qter Tyrosine phosphoprotein SLP-76 −1.91* 
ARL7 2q37.1 ADP-ribosylation factor-like 7 −1.83* 
AIF-1 6p21.3 Allograft-inflammatory factor-1 −1.74 
XPC 3p25 Xeroderma pigmentosum, complementation group C −1.46* 
CD11A 16p11.2 CD11A, Integrin, alpha L; LFA-1 alpha chain −1.46 
DDB2 11p12-p11 Damage-specific DNA binding protein 2 −1.56* 
TP53 17p13.1 p53 Tumor suppressor −1.58 
CABIN1 22q11.23 Negative regulator for calcineurin signaling in T lymphocytes −1.31 
TXNIP 1q21.1 Thioredoxin-interacting protein −1.88 
LILRB1 19q13.4 Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 −1.73 
ARHGEF1 19q13.13 Rho guanine nucleotide exchange factor (GEF) 1 −1.37 
ARRB2 17p13 Arrestin beta 2 −1.42* 
FYN 6q21 Tyrosine protein kinase −1.92* 
FYB 5p13.1 SLAP-130, SLP-76 associated protein; FYN, binding protein −1.85 
DPH2L 17p13.3 Similar to diphthamide biosynthesis gene DPH2 of Saccharomyces cerevisiae −1.33 
CDKN1A (p21) 6p21.2 Cyclin kinase inhibitor, WAF1, CIP1 −1.56 
FCGRT 19q13.3 IgG Fc receptor hFcRn −1.73 
NSF 17q21 Ribosomal protein S7 −1.69 
TCRA 14q11.2 T-cell receptor alpha chain −1.99 
CD64 1q21.1 High-affinity immunoglobulin gamma FC receptor I A −3.36 
PSRY5 13q14 Purinergic receptor P2Y5 −2.30 
LSP1 11p15.5 Lymphocyte-specific protein −1.75* 
BTG1 12q22 B-cell translocation gene 1 −1.61 
TOP3A 17p12-p11.2 Topoisomerase DNA III alpha −1.36 
BAX 19q13.3-4 BCL2-associated X protein −1.52 
GBP2 1p22.2 Guanylate-binding protein 2, interferon-inducible −1.93 
NK4 16p13.3 Interleukin 32 −2.08 
SPAG7 17p13.2 Sperm-associated antigen −1.35 

Only known genes with a P value of < .0001 are listed in ranked order (P values not shown) from the total of 135 differentially expressed genes at P < .001.

*

Average of multiple values.

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