Differential mRNA expression in DLBCL with TP53 mutations
Gene symbol . | Location . | Gene description . | Fold difference . |
---|---|---|---|
TNFRSF10B (DR5) | 8p22-p21 | Tumor necrosis factor receptor superfamily, member 10b (TRAIL receptor 2) | −1.45* |
LCP2 (SLP-76) | 5q33.1-qter | Tyrosine phosphoprotein SLP-76 | −1.91* |
ARL7 | 2q37.1 | ADP-ribosylation factor-like 7 | −1.83* |
AIF-1 | 6p21.3 | Allograft-inflammatory factor-1 | −1.74 |
XPC | 3p25 | Xeroderma pigmentosum, complementation group C | −1.46* |
CD11A | 16p11.2 | CD11A, Integrin, alpha L; LFA-1 alpha chain | −1.46 |
DDB2 | 11p12-p11 | Damage-specific DNA binding protein 2 | −1.56* |
TP53 | 17p13.1 | p53 Tumor suppressor | −1.58 |
CABIN1 | 22q11.23 | Negative regulator for calcineurin signaling in T lymphocytes | −1.31 |
TXNIP | 1q21.1 | Thioredoxin-interacting protein | −1.88 |
LILRB1 | 19q13.4 | Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 | −1.73 |
ARHGEF1 | 19q13.13 | Rho guanine nucleotide exchange factor (GEF) 1 | −1.37 |
ARRB2 | 17p13 | Arrestin beta 2 | −1.42* |
FYN | 6q21 | Tyrosine protein kinase | −1.92* |
FYB | 5p13.1 | SLAP-130, SLP-76 associated protein; FYN, binding protein | −1.85 |
DPH2L | 17p13.3 | Similar to diphthamide biosynthesis gene DPH2 of Saccharomyces cerevisiae | −1.33 |
CDKN1A (p21) | 6p21.2 | Cyclin kinase inhibitor, WAF1, CIP1 | −1.56 |
FCGRT | 19q13.3 | IgG Fc receptor hFcRn | −1.73 |
NSF | 17q21 | Ribosomal protein S7 | −1.69 |
TCRA | 14q11.2 | T-cell receptor alpha chain | −1.99 |
CD64 | 1q21.1 | High-affinity immunoglobulin gamma FC receptor I A | −3.36 |
PSRY5 | 13q14 | Purinergic receptor P2Y5 | −2.30 |
LSP1 | 11p15.5 | Lymphocyte-specific protein | −1.75* |
BTG1 | 12q22 | B-cell translocation gene 1 | −1.61 |
TOP3A | 17p12-p11.2 | Topoisomerase DNA III alpha | −1.36 |
BAX | 19q13.3-4 | BCL2-associated X protein | −1.52 |
GBP2 | 1p22.2 | Guanylate-binding protein 2, interferon-inducible | −1.93 |
NK4 | 16p13.3 | Interleukin 32 | −2.08 |
SPAG7 | 17p13.2 | Sperm-associated antigen | −1.35 |
Gene symbol . | Location . | Gene description . | Fold difference . |
---|---|---|---|
TNFRSF10B (DR5) | 8p22-p21 | Tumor necrosis factor receptor superfamily, member 10b (TRAIL receptor 2) | −1.45* |
LCP2 (SLP-76) | 5q33.1-qter | Tyrosine phosphoprotein SLP-76 | −1.91* |
ARL7 | 2q37.1 | ADP-ribosylation factor-like 7 | −1.83* |
AIF-1 | 6p21.3 | Allograft-inflammatory factor-1 | −1.74 |
XPC | 3p25 | Xeroderma pigmentosum, complementation group C | −1.46* |
CD11A | 16p11.2 | CD11A, Integrin, alpha L; LFA-1 alpha chain | −1.46 |
DDB2 | 11p12-p11 | Damage-specific DNA binding protein 2 | −1.56* |
TP53 | 17p13.1 | p53 Tumor suppressor | −1.58 |
CABIN1 | 22q11.23 | Negative regulator for calcineurin signaling in T lymphocytes | −1.31 |
TXNIP | 1q21.1 | Thioredoxin-interacting protein | −1.88 |
LILRB1 | 19q13.4 | Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 | −1.73 |
ARHGEF1 | 19q13.13 | Rho guanine nucleotide exchange factor (GEF) 1 | −1.37 |
ARRB2 | 17p13 | Arrestin beta 2 | −1.42* |
FYN | 6q21 | Tyrosine protein kinase | −1.92* |
FYB | 5p13.1 | SLAP-130, SLP-76 associated protein; FYN, binding protein | −1.85 |
DPH2L | 17p13.3 | Similar to diphthamide biosynthesis gene DPH2 of Saccharomyces cerevisiae | −1.33 |
CDKN1A (p21) | 6p21.2 | Cyclin kinase inhibitor, WAF1, CIP1 | −1.56 |
FCGRT | 19q13.3 | IgG Fc receptor hFcRn | −1.73 |
NSF | 17q21 | Ribosomal protein S7 | −1.69 |
TCRA | 14q11.2 | T-cell receptor alpha chain | −1.99 |
CD64 | 1q21.1 | High-affinity immunoglobulin gamma FC receptor I A | −3.36 |
PSRY5 | 13q14 | Purinergic receptor P2Y5 | −2.30 |
LSP1 | 11p15.5 | Lymphocyte-specific protein | −1.75* |
BTG1 | 12q22 | B-cell translocation gene 1 | −1.61 |
TOP3A | 17p12-p11.2 | Topoisomerase DNA III alpha | −1.36 |
BAX | 19q13.3-4 | BCL2-associated X protein | −1.52 |
GBP2 | 1p22.2 | Guanylate-binding protein 2, interferon-inducible | −1.93 |
NK4 | 16p13.3 | Interleukin 32 | −2.08 |
SPAG7 | 17p13.2 | Sperm-associated antigen | −1.35 |
Only known genes with a P value of < .0001 are listed in ranked order (P values not shown) from the total of 135 differentially expressed genes at P < .001.
Average of multiple values.