The effect of PGE2 on the expression of MMPs and TIMPs
| Extracellular matrix proteins . | Other name . | Fold change* . |
|---|---|---|
| MMP-1 | Collagenase-1 | 1.96 |
| MMP-2 | Gelatinase A | -2.29 |
| MMP-3 | Stromelysin-1 | 2.51 |
| MMP-7 | Uterine metalloproteinase | 2.67 |
| MMP-8 | Collagenase-2 | 1.36 |
| MMP-9 | Gelatinase B | 26.51 |
| MMP-10 | Stromelysin-2 | 4.89 |
| MMP-11 | Stromelysin-3 | 3.12 |
| MMP-12 | Metalloelastase | -1.01 |
| MMP-13 | Collagenase-3 | 2.37 |
| MMP-14 | Membrane-type 1 MMP (MT1-MMP) | 1.11 |
| MMP-15 | Membrane-type 2 MMP (MT2-MMP) | 2.88 |
| TIMP-1 | Tissue inhibitor of metalloproteinase 1 | 2.58 |
| TIMP-2 | Tissue inhibitor of metalloproteinase 2 | 1.27 |
| TIMP-3 | Tissue inhibitor of metalloproteinase 3 | 1.80 |
| Extracellular matrix proteins . | Other name . | Fold change* . |
|---|---|---|
| MMP-1 | Collagenase-1 | 1.96 |
| MMP-2 | Gelatinase A | -2.29 |
| MMP-3 | Stromelysin-1 | 2.51 |
| MMP-7 | Uterine metalloproteinase | 2.67 |
| MMP-8 | Collagenase-2 | 1.36 |
| MMP-9 | Gelatinase B | 26.51 |
| MMP-10 | Stromelysin-2 | 4.89 |
| MMP-11 | Stromelysin-3 | 3.12 |
| MMP-12 | Metalloelastase | -1.01 |
| MMP-13 | Collagenase-3 | 2.37 |
| MMP-14 | Membrane-type 1 MMP (MT1-MMP) | 1.11 |
| MMP-15 | Membrane-type 2 MMP (MT2-MMP) | 2.88 |
| TIMP-1 | Tissue inhibitor of metalloproteinase 1 | 2.58 |
| TIMP-2 | Tissue inhibitor of metalloproteinase 2 | 1.27 |
| TIMP-3 | Tissue inhibitor of metalloproteinase 3 | 1.80 |
Purified CD11c+ bone marrow–derived DCs were stimulated with PGE2 (10−6 M) for 24 hours. RNA was extracted and converted to cDNA. cDNA was diluted according to the manufacturer's instruction and subjected to (RT)2-profiler PCR array. One representative experiment of 3 is shown.
Gene expression levels of PGE2-treated DCs divided by gene expression levelsof untreated DCs.