Table 3

Event-based grade 3 and 4 laboratory toxicity as percentage of total number of treatment cycles administered attributed as possible, probable, or definite to study treatment

ToxicityGrade 3
Grade 4
InductionMaintenanceOverallInductionMaintenanceOverall
Leukopenia 13.78 2.90 7.78 0.51 0 0.23 
Neutropenia 28.57 12.86 19.91 6.12 3.32 4.58 
Lymphopenia 0.51 0 0.23 0 0 0 
Anemia 0.51 0.41 0.46 0 0 0 
Thrombocytopenia 0 0.83 0.46 0 0.41 0.23 
Hemolysis 0 0.41 0.23 0 0 0 
Aminotransferase       
    Aspartate 5.61 4.98 5.26 0 0.41 0.23 
    Alanine 4.08 7.88 6.18 1.02 0.41 0.69 
ToxicityGrade 3
Grade 4
InductionMaintenanceOverallInductionMaintenanceOverall
Leukopenia 13.78 2.90 7.78 0.51 0 0.23 
Neutropenia 28.57 12.86 19.91 6.12 3.32 4.58 
Lymphopenia 0.51 0 0.23 0 0 0 
Anemia 0.51 0.41 0.46 0 0 0 
Thrombocytopenia 0 0.83 0.46 0 0.41 0.23 
Hemolysis 0 0.41 0.23 0 0 0 
Aminotransferase       
    Aspartate 5.61 4.98 5.26 0 0.41 0.23 
    Alanine 4.08 7.88 6.18 1.02 0.41 0.69 

Induction was 196 cycles, maintenance was 241 cycles, and there were overall 437 cycles of therapy. Data are all percentages of numbers of cycles.

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