Table 1

Hematologic parameters of experimental mice

Retroviral constructMice analyzed, no.Median day of killing (range)Mean RBC, ×109/mL (± SD)Mean WBC, × 106/mL (± SD)Mean spleen weight, mg (± SD)BM, % blasts (± SD)Spleen, % blasts (± SD)PB, % blasts (± SD)Lymphoid/myeloid ratio in PB
EGFP 6 123.5 (85-127)* 5.67 (± 0.93) 3.37 (± 2.61) 156 (± 59)† 0 0 0 5:1 
Cdx2 15 111 (37-229) 1.22 (± 0.43) 22.87 (± 14.68) 546 (± 195) 45 (± 15) 38 (± 15) 18 (± 10) 2:1 
W167A 6 128.5 (46-381) 0.93 (± 0.35) 33.5 (± 32.25) 516 (± 233) 50 (± 12) 34 (± 9) 27 (± 2) 2:1 
ΔN-Cdx2 3 330 (309-350) 4.4 (± 0.75) 5.3 (± 1.42) 210 (± 90) 6 0 0 4:1 
Retroviral constructMice analyzed, no.Median day of killing (range)Mean RBC, ×109/mL (± SD)Mean WBC, × 106/mL (± SD)Mean spleen weight, mg (± SD)BM, % blasts (± SD)Spleen, % blasts (± SD)PB, % blasts (± SD)Lymphoid/myeloid ratio in PB
EGFP 6 123.5 (85-127)* 5.67 (± 0.93) 3.37 (± 2.61) 156 (± 59)† 0 0 0 5:1 
Cdx2 15 111 (37-229) 1.22 (± 0.43) 22.87 (± 14.68) 546 (± 195) 45 (± 15) 38 (± 15) 18 (± 10) 2:1 
W167A 6 128.5 (46-381) 0.93 (± 0.35) 33.5 (± 32.25) 516 (± 233) 50 (± 12) 34 (± 9) 27 (± 2) 2:1 
ΔN-Cdx2 3 330 (309-350) 4.4 (± 0.75) 5.3 (± 1.42) 210 (± 90) 6 0 0 4:1 
*

A total of 4 of 6 healthy EGFP mice were killed for analysis. A total of 2 of the 6 control mice were analyzed by bone marrow biopsy and bleeding.

†

Average weight from 4 EGFP mice.

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