Altered glutamine and glutathione precursors in erythrocytes of SCD patients compared with healthy volunteers, and in SCD patients by tricuspid regurgitant jet velocity
| GSH precursors (μM) . | Erythrocytes . | SCD Erythrocyte . | ||||
|---|---|---|---|---|---|---|
| Controls . | SCD . | P . | TRV under 2.5 m/s . | TRV 2.5 m/s or more . | P . | |
| Glutamate | 178 ± 11 | 288 ± 35 | .004* | 327 ± 49 | 235 ± 47 | .2 |
| Cysteine | 15 ± 2 | 21 ± 6 | 0.3* | 18 ± 5 | 22 ± 7 | .7 |
| Glycine | 274 ± 28 | 497 ± 63 | .002* | 519 ± 73 | 468 ± 113 | .1 |
| Glutamine | 990 ± 94 | 742 ± 99 | .08* | 934 ± 148 | 482 ± 92 | .01* |
| GSH precursors (μM) . | Erythrocytes . | SCD Erythrocyte . | ||||
|---|---|---|---|---|---|---|
| Controls . | SCD . | P . | TRV under 2.5 m/s . | TRV 2.5 m/s or more . | P . | |
| Glutamate | 178 ± 11 | 288 ± 35 | .004* | 327 ± 49 | 235 ± 47 | .2 |
| Cysteine | 15 ± 2 | 21 ± 6 | 0.3* | 18 ± 5 | 22 ± 7 | .7 |
| Glycine | 274 ± 28 | 497 ± 63 | .002* | 519 ± 73 | 468 ± 113 | .1 |
| Glutamine | 990 ± 94 | 742 ± 99 | .08* | 934 ± 148 | 482 ± 92 | .01* |
Data are shown as average plus or minus SEM.
Unpaired t test performed with Welch correction for unequal variance.