Details of NOTCH1 mutations in 4 cases of T-ALL
| Patients . | Age at diagnosis . | Mutations in NOTCH1 . | SIL-TAL1 . |
|---|---|---|---|
| MGT01 | 6 y 10 mon | HD; 4894ins (-TCTTACCGAGAAACGAAGACAAG-) | + (Type I) |
| MGT09 | 9 y 1 mon | HD; 4894ins (-TCTTTGTCGCCAAG-) | − |
| MGT10 | 4 y 7 mon | PEST; 7123ins (-GCCCTCCCTGCAGCATGGTAGGTGAGGCCCTCCC-)* | − |
| MGT11 | 5 y 6 mon | PEST; 7403ins (-AGACTGCACTGCA-) | − |
| Patients . | Age at diagnosis . | Mutations in NOTCH1 . | SIL-TAL1 . |
|---|---|---|---|
| MGT01 | 6 y 10 mon | HD; 4894ins (-TCTTACCGAGAAACGAAGACAAG-) | + (Type I) |
| MGT09 | 9 y 1 mon | HD; 4894ins (-TCTTTGTCGCCAAG-) | − |
| MGT10 | 4 y 7 mon | PEST; 7123ins (-GCCCTCCCTGCAGCATGGTAGGTGAGGCCCTCCC-)* | − |
| MGT11 | 5 y 6 mon | PEST; 7403ins (-AGACTGCACTGCA-) | − |
Sequences of patient-specific insertional mutation are underlined.
+ indicates present, −, not present.
dup(7097-7122).