Table 2

Multivariate analysis of overall survival in 86 T-PLL patients based on Cox proportional hazards model integrating molecular and clinical features

Prognostic factorRisk of disease-related death
Relative riskStandard errorP
Model including tumor features and age 
    Age over 65 y 1.9 0.26 .015 
    High TCL1 1.7 0.28 .049 
    pAKT-S473+ 2.9 0.45 .03 
    sTCR+ 2.2 0.37 .02 
Model with inclusion of clinical parameters 
    Age over 65 y 2.4 0.27 .001 
    WBC count over 40 ×109/L* 2.2 0.28 .006 
    LDT, 3-tier* 2.2 0.22 <.001 
    sTCR+ 2.6 0.37 .01 
Prognostic factorRisk of disease-related death
Relative riskStandard errorP
Model including tumor features and age 
    Age over 65 y 1.9 0.26 .015 
    High TCL1 1.7 0.28 .049 
    pAKT-S473+ 2.9 0.45 .03 
    sTCR+ 2.2 0.37 .02 
Model with inclusion of clinical parameters 
    Age over 65 y 2.4 0.27 .001 
    WBC count over 40 ×109/L* 2.2 0.28 .006 
    LDT, 3-tier* 2.2 0.22 <.001 
    sTCR+ 2.6 0.37 .01 
*

Both TCL1 and pAKT levels showed a strong positive correlation with each of these clinical parameters and were therefore not retained in this regression analysis.

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