Summary of systematic review characteristics
| Study . | Time period . | Study designs included . | ESA . | Indication for ESA . | ||
|---|---|---|---|---|---|---|
| CT-induced anemia . | Anemia of cancer . | MDS . | ||||
| Seidenfeld et al 20064 | 1985–2005 | RCTs | EPO-α, EPO-β, and DAR | 59 studies (n = 11,757) | ||
| Bohlius et al 20063 (Cochrane); Bohlius et al 2006 (JNCI) 39 | Studies from January 1, 1985 to December 31, 2001 for first Cochrane review; January 1, 2002 to April 13, 2005 | RCTs | EPO-α, EPO-β, and DAR | 57 studies (n = 9353)* | ||
| Quirt et al 20056 | 1966–2005 | RCTs | EPO-α, EPO-β, and DAR | NR | NR | NR |
| Shehata et al 20077 | 1985–2005 | RCTs | EPO-α, EPO-β, and DAR-α | NR | NR | NR |
| Wilson et al 20075 | 2000–2004 (EPO-α and EPO-β); 1996–2004 (DAR) | RCTs | EPO-α, EPO-β, and DAR (collapsed into one ESA category) | NR | 4 studies (n = 386) | 3 studies (n = 192) |
| Study . | Time period . | Study designs included . | ESA . | Indication for ESA . | ||
|---|---|---|---|---|---|---|
| CT-induced anemia . | Anemia of cancer . | MDS . | ||||
| Seidenfeld et al 20064 | 1985–2005 | RCTs | EPO-α, EPO-β, and DAR | 59 studies (n = 11,757) | ||
| Bohlius et al 20063 (Cochrane); Bohlius et al 2006 (JNCI) 39 | Studies from January 1, 1985 to December 31, 2001 for first Cochrane review; January 1, 2002 to April 13, 2005 | RCTs | EPO-α, EPO-β, and DAR | 57 studies (n = 9353)* | ||
| Quirt et al 20056 | 1966–2005 | RCTs | EPO-α, EPO-β, and DAR | NR | NR | NR |
| Shehata et al 20077 | 1985–2005 | RCTs | EPO-α, EPO-β, and DAR-α | NR | NR | NR |
| Wilson et al 20075 | 2000–2004 (EPO-α and EPO-β); 1996–2004 (DAR) | RCTs | EPO-α, EPO-β, and DAR (collapsed into one ESA category) | NR | 4 studies (n = 386) | 3 studies (n = 192) |
Abbreviations: ESA, erythropoiesis-stimulating agent; CT, chemotherapy; MDS, myelodysplastic syndrome; RCT, randomized controlled trial; NR, not reported; EPO-α, epoetin alfa; EPO-β, Epoetin beta; DAR, darbepoetin; DAR-α, darbepoetin alfa; NR, not reported.
Represents total number of studies, not restricted to CT-induced anemia, although majority of these studies were in this population.