Non-hematological ATO-related toxicity in subsequent cycles
| Toxicity . | Grade . | Patients, no. . | Cycle no. . |
|---|---|---|---|
| Cardiovascular | |||
| Prolonged QTc | 1 | 1 | 2 |
| Tachycardia* | 1 | 1 | 2 |
| Hypotension* | 3 | 1 | 2 |
| Coagulation, elevated PTT | 1 | 1 | 3 |
| Constitutional, nasal congestion* | 1 | 1 | 3 |
| Gastrointestinal | |||
| Vomiting* | 1 | 1 | 2 |
| Nausea* | 1 | 2 | 2 |
| Diarrhea* | 1 | 1 | 2 |
| Stomatitis* | 1 | 1 | 2 |
| Hepatic, elevated AST* | 1 | 1 | 2 |
| Metabolic | |||
| Hypokalemia | 1 | 1 | 3 |
| Hypomagnesemia | 1 | 1 | 2 |
| Hypomagnesemia | 3 | 1 | 2 |
| Hypocalcemia | 1 | 1 | 3 |
| Hypocalcemia* | 1 | 1 | 2 |
| Hypocalcemia* | 3 | 1 | 2 |
| Hyperglycemia* | 1 | 2 | 2 |
| Hyperglycemia* | 1 | 1 | 3 |
| Neurological | |||
| Motor neuropathy* | 1 | 1 | 2 |
| Tremor* | 1 | 1 | 2 |
| Tremor* | 1 | 1 | 3 |
| Pain | |||
| Headache* | 1 | 1 | 2 |
| Pain (bone)* | 1 | 1 | 2 |
| Pulmonary, shortness of breath* | 1 | 1 | 2 |
| Toxicity . | Grade . | Patients, no. . | Cycle no. . |
|---|---|---|---|
| Cardiovascular | |||
| Prolonged QTc | 1 | 1 | 2 |
| Tachycardia* | 1 | 1 | 2 |
| Hypotension* | 3 | 1 | 2 |
| Coagulation, elevated PTT | 1 | 1 | 3 |
| Constitutional, nasal congestion* | 1 | 1 | 3 |
| Gastrointestinal | |||
| Vomiting* | 1 | 1 | 2 |
| Nausea* | 1 | 2 | 2 |
| Diarrhea* | 1 | 1 | 2 |
| Stomatitis* | 1 | 1 | 2 |
| Hepatic, elevated AST* | 1 | 1 | 2 |
| Metabolic | |||
| Hypokalemia | 1 | 1 | 3 |
| Hypomagnesemia | 1 | 1 | 2 |
| Hypomagnesemia | 3 | 1 | 2 |
| Hypocalcemia | 1 | 1 | 3 |
| Hypocalcemia* | 1 | 1 | 2 |
| Hypocalcemia* | 3 | 1 | 2 |
| Hyperglycemia* | 1 | 2 | 2 |
| Hyperglycemia* | 1 | 1 | 3 |
| Neurological | |||
| Motor neuropathy* | 1 | 1 | 2 |
| Tremor* | 1 | 1 | 2 |
| Tremor* | 1 | 1 | 3 |
| Pain | |||
| Headache* | 1 | 1 | 2 |
| Pain (bone)* | 1 | 1 | 2 |
| Pulmonary, shortness of breath* | 1 | 1 | 2 |
Occurred in patients receiving ATO based on ideal body weight (actual doses 0.05 to 0.1 mg/kg).