Epidemiologic data (n = 303)
| Characteristics . | Records, no. . | Clinical data . |
|---|---|---|
| Sex | 302 | 169 females, 133 males |
| Year of birth (± SD) | 300 | 1957 (± 17) |
| Age at onset, y (± SD) | 156 | 27 (± 17) |
| Age at diagnosis | 289 | 35 (± 16) |
| Splenomegaly, % | 284 | 40.5 |
| Lymphadenopathy, % | 260 | 26.2 |
| Granulomatous disease, % | 303 | 11.6 |
| Autoimmune phenomena, % | 286 | 20.3 |
| Autoimmune cytopenia, % | 213 | 20.2 |
| Characteristics . | Records, no. . | Clinical data . |
|---|---|---|
| Sex | 302 | 169 females, 133 males |
| Year of birth (± SD) | 300 | 1957 (± 17) |
| Age at onset, y (± SD) | 156 | 27 (± 17) |
| Age at diagnosis | 289 | 35 (± 16) |
| Splenomegaly, % | 284 | 40.5 |
| Lymphadenopathy, % | 260 | 26.2 |
| Granulomatous disease, % | 303 | 11.6 |
| Autoimmune phenomena, % | 286 | 20.3 |
| Autoimmune cytopenia, % | 213 | 20.2 |
Description of the European cohort, including sex, age, age of onset, age of diagnosis, and associated clinical phenomena of the 303 patients included in this trial. Splenomegaly was defined by ultrasound or CT scan to be larger than 4.7 × 11 cm. Lymphadenopathy was defined by clinical examination or ultrasound or CT scan. Granulomatous disease was judged positive only in histologically proven cases. All others were assumed negative. Autoimmune phenomena other than cytopenia included autoimmune thyroiditis, vitiligo, and pernicious anemia. Autoimmune cytopenia refers to AIHA and AITP.