Risk-stratification models to predict progression of SMM to myeloma or related disorders
| Addition of FLC ratio to known prognostic categories . | Patients, no. . | Relative risk (95% CI) . | P . | Absolute risk of progression at 10 y, % (% corrected for death as competing risk) . |
|---|---|---|---|---|
| High-risk (serum M protein 30 gm/L or more and BMPC 10% or more) | ||||
| FLC ratio 0.125 to 8 | 28 | 1 | .011 | 58.8 (51.3) |
| FLC ratio less than 0.125 or more than 8 | 78 | 2.06 (1.18-3.59) | — | 83.8 (75.2) |
| Intermediate-risk (serum M protein less than 30 gm/L and BMPC 10% or more) | ||||
| FLC ratio 0.125 to 8 | 58 | 1 | .028 | 58.3 (40.4) |
| FLC ratio less than 0.125 or more than 8 | 82 | 1.72 (1.06-2.80) | — | 68.5 (56.8) |
| Low-risk (serum M protein 30 gm/L or more and BMPC less than 10%) | ||||
| FLC ratio 0.125 to 8 | 23 | 1 | .96 | 32.2 (22.8) |
| FLC ratio less than 0.125 or more than 8 | 4 | 1.05 (0.21-5.32) | — | 33.3 (25.0) |
| Addition of FLC ratio to known prognostic categories . | Patients, no. . | Relative risk (95% CI) . | P . | Absolute risk of progression at 10 y, % (% corrected for death as competing risk) . |
|---|---|---|---|---|
| High-risk (serum M protein 30 gm/L or more and BMPC 10% or more) | ||||
| FLC ratio 0.125 to 8 | 28 | 1 | .011 | 58.8 (51.3) |
| FLC ratio less than 0.125 or more than 8 | 78 | 2.06 (1.18-3.59) | — | 83.8 (75.2) |
| Intermediate-risk (serum M protein less than 30 gm/L and BMPC 10% or more) | ||||
| FLC ratio 0.125 to 8 | 58 | 1 | .028 | 58.3 (40.4) |
| FLC ratio less than 0.125 or more than 8 | 82 | 1.72 (1.06-2.80) | — | 68.5 (56.8) |
| Low-risk (serum M protein 30 gm/L or more and BMPC less than 10%) | ||||
| FLC ratio 0.125 to 8 | 23 | 1 | .96 | 32.2 (22.8) |
| FLC ratio less than 0.125 or more than 8 | 4 | 1.05 (0.21-5.32) | — | 33.3 (25.0) |
— indicates not applicable.