Clinical features of B-CLL patients
| . | Binet stage . | Mutational status . | Del 13q14 . | del 11q22 . | +12 . | del 17p13 . | Karyotype analysis . |
|---|---|---|---|---|---|---|---|
| LLC′1 | A | UM | + | — | — | — | ND |
| LLC′3 | A | M | — | — | — | + | ND |
| LLC′7 | A | M | — | — | — | — | N |
| LLC′9 | A | M | ND | ND | ND | ND | ND |
| LLC′11 | A | M | + | — | — | — | ND |
| LLC′26 | A | ND | ND | ND | ND | ND | ND |
| LLC′19 | A+ | ND | ND | ND | ND | ND | ND |
| LLC′23 | A+ | M | + | — | — | + | ND |
| LLC′28 | A | M | + | — | — | + | ND |
| LLC′31 | A+ | UM | — | — | + | — | +12, t(14;19) |
| LLC′32 | A | M | — | — | + | — | ND |
| LLC′13 | B | UM | + | — | — | — | ND |
| LLC′14 | A+ | M | + | — | — | — | ND |
| LLC′17 | A | ND | ND | ND | ND | ND | ND |
| LLC′29 | A | ND | ND | ND | ND | ND | ND |
| LLC′15 | B | UM | + | — | — | — | ND |
| LLC2 | A | M | — | — | — | — | N |
| LLC3 | NA | M | + | — | — | — | del 13(q13q14) |
| LLC5 | NA | M | + | — | — | — | del 13(q22q31) |
| LLC6 | A | M | + | — | — | — | N |
| LLC7 | A | UM | — | — | — | — | N |
| LLC9 | A+ | UM | — | — | — | — | N |
| LLC 11 | A | UM | + | — | — | — | add 14q32/del 13q(q12-q22) |
| LLC18 | A | M | ND | ND | ND | ND | ND |
| LLC21 | A/B | M | ND | ND | ND | ND | ND |
| LLC23 | B+ | M | + | — | — | — | 13q21abnormality |
| LLC30 | A | M | + | — | — | — | N |
| LLC31 | A+ | M | + | — | — | + | t(11;14)/del17p11 |
| LLC33 | A | M | + | — | — | — | N |
| LLC34 | A | UM | + | — | — | — | N |
| LLC39 | C | M | + | — | — | — | N |
| LLC41 | A | M | + | — | — | — | t(14;18)(q32;q21) |
| LLC44 | A | M | + | — | — | — | del13q |
| LLC47 | A | M | ND | ND | ND | ND | ND |
| LLC50 | C | M | — | — | — | — | N |
| LLC51 | A | M | — | — | — | — | N |
| LLC54 | A | M | + | — | — | — | N |
| LLC55 | A | M | + | — | — | — | del6q |
| LLC56 | B | UM | — | — | + | — | +12 |
| LLC57 | NA | M | — | — | — | — | t(7;22) |
| LLC95 | NA | UM | — | — | — | — | N |
| LLC98 | A | M | + | — | — | — | N |
| . | Binet stage . | Mutational status . | Del 13q14 . | del 11q22 . | +12 . | del 17p13 . | Karyotype analysis . |
|---|---|---|---|---|---|---|---|
| LLC′1 | A | UM | + | — | — | — | ND |
| LLC′3 | A | M | — | — | — | + | ND |
| LLC′7 | A | M | — | — | — | — | N |
| LLC′9 | A | M | ND | ND | ND | ND | ND |
| LLC′11 | A | M | + | — | — | — | ND |
| LLC′26 | A | ND | ND | ND | ND | ND | ND |
| LLC′19 | A+ | ND | ND | ND | ND | ND | ND |
| LLC′23 | A+ | M | + | — | — | + | ND |
| LLC′28 | A | M | + | — | — | + | ND |
| LLC′31 | A+ | UM | — | — | + | — | +12, t(14;19) |
| LLC′32 | A | M | — | — | + | — | ND |
| LLC′13 | B | UM | + | — | — | — | ND |
| LLC′14 | A+ | M | + | — | — | — | ND |
| LLC′17 | A | ND | ND | ND | ND | ND | ND |
| LLC′29 | A | ND | ND | ND | ND | ND | ND |
| LLC′15 | B | UM | + | — | — | — | ND |
| LLC2 | A | M | — | — | — | — | N |
| LLC3 | NA | M | + | — | — | — | del 13(q13q14) |
| LLC5 | NA | M | + | — | — | — | del 13(q22q31) |
| LLC6 | A | M | + | — | — | — | N |
| LLC7 | A | UM | — | — | — | — | N |
| LLC9 | A+ | UM | — | — | — | — | N |
| LLC 11 | A | UM | + | — | — | — | add 14q32/del 13q(q12-q22) |
| LLC18 | A | M | ND | ND | ND | ND | ND |
| LLC21 | A/B | M | ND | ND | ND | ND | ND |
| LLC23 | B+ | M | + | — | — | — | 13q21abnormality |
| LLC30 | A | M | + | — | — | — | N |
| LLC31 | A+ | M | + | — | — | + | t(11;14)/del17p11 |
| LLC33 | A | M | + | — | — | — | N |
| LLC34 | A | UM | + | — | — | — | N |
| LLC39 | C | M | + | — | — | — | N |
| LLC41 | A | M | + | — | — | — | t(14;18)(q32;q21) |
| LLC44 | A | M | + | — | — | — | del13q |
| LLC47 | A | M | ND | ND | ND | ND | ND |
| LLC50 | C | M | — | — | — | — | N |
| LLC51 | A | M | — | — | — | — | N |
| LLC54 | A | M | + | — | — | — | N |
| LLC55 | A | M | + | — | — | — | del6q |
| LLC56 | B | UM | — | — | + | — | +12 |
| LLC57 | NA | M | — | — | — | — | t(7;22) |
| LLC95 | NA | UM | — | — | — | — | N |
| LLC98 | A | M | + | — | — | — | N |
FISH analyses were led to determine 13q14, 17p13, 11q22 deletion and trisomy 12 (+12).
ND indicates not done; NA, not available; N, normal; +, previously treated; M, mutated; UM, unmutated; add, addition; del, deletion; t, translocation; and —, not applicable.