Reduction in hemolysis and transfusion requirements and improvement in fatigue in patients treated with eculizumab
| . | LDH AUC . | Units of packed RBCs transfused, median (mean ± SE) . | Transfusion independence . | FACIT-Fatigue . | |||||
|---|---|---|---|---|---|---|---|---|---|
| No. . | Median change, U/L × d . | One y before eculizumab . | One y during eculizumab . | P . | % of patientsachieving . | *P value . | No. . | Median change . | |
| Overall | 97 | −632264 | 8.0 (12.3 ± 1.25) | 0.0 (5.9 ± 1.06) | <.001 | 51 | <.001 | 95 | 10.0 |
| Baseline LDH quartile, U/L | |||||||||
| 537–1379 | 25 | −275588 | 8.0 (11.3 ± 2.21) | 0.0 (7.6 ± 2.41) | .143 | 60 | <.001 | 23 | 8.0 |
| 1380–2050 | 24 | −491610 | 7.5 (11.3 ± 2.38) | 1.0 (7.9 ± 2.77) | .033 | 50 | .021 | 24 | 9.0 |
| 2051–2866 | 24 | −811231 | 9.5 (14.3 ± 3.15) | 0.5 (2.6 ± 0.91) | <.001 | 50 | <.001 | 24 | 10.5 |
| 2867–5245 | 24 | −1044117 | 8.5 (12.3 ± 2.27) | 2.0 (5.4 ± 1.82) | .006 | 42 | .021 | 24 | 15.5 |
| Baseline platelet counts, ×109/L | |||||||||
| Less than 65 | 18 | −406663 | 16.0 (20.2 ± 3.21) | 7.5 (11.6 ± 3.46) | .047 | 44 | <.001 | 17 | 8.0 |
| 65 or more | 79 | −667992 | 7.0 (10.5 ± 1.27) | 0.0 (4.6 ± 0.99) | <.001 | 52 | <.001 | 78 | 10.0 |
| . | LDH AUC . | Units of packed RBCs transfused, median (mean ± SE) . | Transfusion independence . | FACIT-Fatigue . | |||||
|---|---|---|---|---|---|---|---|---|---|
| No. . | Median change, U/L × d . | One y before eculizumab . | One y during eculizumab . | P . | % of patientsachieving . | *P value . | No. . | Median change . | |
| Overall | 97 | −632264 | 8.0 (12.3 ± 1.25) | 0.0 (5.9 ± 1.06) | <.001 | 51 | <.001 | 95 | 10.0 |
| Baseline LDH quartile, U/L | |||||||||
| 537–1379 | 25 | −275588 | 8.0 (11.3 ± 2.21) | 0.0 (7.6 ± 2.41) | .143 | 60 | <.001 | 23 | 8.0 |
| 1380–2050 | 24 | −491610 | 7.5 (11.3 ± 2.38) | 1.0 (7.9 ± 2.77) | .033 | 50 | .021 | 24 | 9.0 |
| 2051–2866 | 24 | −811231 | 9.5 (14.3 ± 3.15) | 0.5 (2.6 ± 0.91) | <.001 | 50 | <.001 | 24 | 10.5 |
| 2867–5245 | 24 | −1044117 | 8.5 (12.3 ± 2.27) | 2.0 (5.4 ± 1.82) | .006 | 42 | .021 | 24 | 15.5 |
| Baseline platelet counts, ×109/L | |||||||||
| Less than 65 | 18 | −406663 | 16.0 (20.2 ± 3.21) | 7.5 (11.6 ± 3.46) | .047 | 44 | <.001 | 17 | 8.0 |
| 65 or more | 79 | −667992 | 7.0 (10.5 ± 1.27) | 0.0 (4.6 ± 0.99) | <.001 | 52 | <.001 | 78 | 10.0 |
P values for LDH AUC and FACIT-Fatigue were all < .001.
LDH indicates lactate dehydrogenase; AUC, area under the curve; RBCs, red blood cells; and FACIT, Functional Assessment of Chronic Illness Therapy.
P value is based on an exact McNemar test or chi-square test. All other P values are based on a signed rank test.