Properties of the cell lines used
| Cell lines . | Lymphoma type . | Signalosome assembly . | Activation receptors . | Src kinases . | Oncogenic proteins . | EBV expression . |
|---|---|---|---|---|---|---|
| Raji | B-NHL, Burkitt-derived | Yes | CD40, BCR | Lyn | C-Myc | Yes |
| DoHH2 | B-NHL, follicular immunoblastic | Yes | CD40, BCR | Lyn | Bcl-2 | No |
| SUDHL6 | B-NHL DLBCL GC-type | Yes | BCR | Lyn | Bcl-2 | No |
| SupM2 | T lymphoma ALCL, ALK+ | No | CD30 | Lyn, Lck, Fyn | NPM-ALK | No |
| SR786 | T lymphoma ALCL, ALK+ | No | CD30 | Lyn, Lck, Fyn | NPM-ALK | No |
| Karpas 299 | T lymphoma ALCL, ALK+ | No | CD30 | Lyn, Lck, Fyn | NPM-ALK | No |
| L428 | Hodgkin | No | CD30 | Lyn | ? | No |
| L591 | Hodgkin | No | CD30 | Lyn | ? | Yes |
| Jeko-1 | B-NHL, MCL | Yes | ? | Lyn | Cyclin D1 | No |
| Granta-519 | B-NHL, MCL | Yes | ? | Lyn | Cyclin D1 | Yes |
| OCI-LY3 | B-NHL, DLBCL, ABC-type | Yes | ? | Lyn | ? | No |
| VAL | B-NHL, DLBCL, ABC-type | Yes | ? | Lyn | Bcl-2 | Yes |
| Cell lines . | Lymphoma type . | Signalosome assembly . | Activation receptors . | Src kinases . | Oncogenic proteins . | EBV expression . |
|---|---|---|---|---|---|---|
| Raji | B-NHL, Burkitt-derived | Yes | CD40, BCR | Lyn | C-Myc | Yes |
| DoHH2 | B-NHL, follicular immunoblastic | Yes | CD40, BCR | Lyn | Bcl-2 | No |
| SUDHL6 | B-NHL DLBCL GC-type | Yes | BCR | Lyn | Bcl-2 | No |
| SupM2 | T lymphoma ALCL, ALK+ | No | CD30 | Lyn, Lck, Fyn | NPM-ALK | No |
| SR786 | T lymphoma ALCL, ALK+ | No | CD30 | Lyn, Lck, Fyn | NPM-ALK | No |
| Karpas 299 | T lymphoma ALCL, ALK+ | No | CD30 | Lyn, Lck, Fyn | NPM-ALK | No |
| L428 | Hodgkin | No | CD30 | Lyn | ? | No |
| L591 | Hodgkin | No | CD30 | Lyn | ? | Yes |
| Jeko-1 | B-NHL, MCL | Yes | ? | Lyn | Cyclin D1 | No |
| Granta-519 | B-NHL, MCL | Yes | ? | Lyn | Cyclin D1 | Yes |
| OCI-LY3 | B-NHL, DLBCL, ABC-type | Yes | ? | Lyn | ? | No |
| VAL | B-NHL, DLBCL, ABC-type | Yes | ? | Lyn | Bcl-2 | Yes |
EBV indicates Epstein-Barr virus; B-NHL, B-non-Hodgkin lymphoma; DLBCL, diffuse large B-cell lymphoma; GC, germinal center; ALCL, anaplastic large cell T lymphoma; ALK, anaplastic lymphoma kinase; MCL, mantle cell lymphoma; ABC, activated B-cell; and ?, unknown.