Potency of compounds in various cellular assay
| Cell assay . | Kinases . | Compounds . | |||
|---|---|---|---|---|---|
| CP-690550 . | PF-956980 . | WHI-P131 . | WHI-P154 . | ||
| DND39 | JAK1, JAK3 | 21 | 23 | >10 000 | >10 000 |
| HUO3 | JAK2 | 324 | 188 | >10 000 | NT |
| HFF | Nonspecific | >10 000 | >10 000 | >10 000 | 6343 |
| Whole blood | JAK1, JAK3 | 25 | 121 | NT | NT |
| EGF | EGFR | NT | NT | 405 | <100 |
| Cell assay . | Kinases . | Compounds . | |||
|---|---|---|---|---|---|
| CP-690550 . | PF-956980 . | WHI-P131 . | WHI-P154 . | ||
| DND39 | JAK1, JAK3 | 21 | 23 | >10 000 | >10 000 |
| HUO3 | JAK2 | 324 | 188 | >10 000 | NT |
| HFF | Nonspecific | >10 000 | >10 000 | >10 000 | 6343 |
| Whole blood | JAK1, JAK3 | 25 | 121 | NT | NT |
| EGF | EGFR | NT | NT | 405 | <100 |
All potencies are shown as IC50 in nM, and are the mean values of at least three independent determinations.
NT indicates not tested.